摘要
胃癌是消化道最常见的恶性肿瘤之一,恶性程度高且预后差,其发生是环境、饮食、幽门螺杆菌感染及遗传等多因素交互作用的结果。随着对胃癌研究的不断深入,表观遗传学改变在胃癌发病过程中的作用已成为近年来的研究热点。表观遗传学主要研究在基因序列不发生改变的情况下,基因功能及表达水平发生的改变,已知的方式主要有DNA甲基化、组蛋白修饰、非编码RNA的调控等。表观遗传变化在胃癌诊断和预后中的应用可能成为胃癌治疗的新方向。
Gastric cancer is one of the most common malignant tumors in the digestive tract, with high malignant degree and poor prognosis, and the occurrence of gastric cancer is the result of multi-factor interaction such as environment, diet, helicobacter pylori infection and inheritance. With the deepening of the study on gastric cancer, the role of epigenetic chan- ges in the pathogenesis of gastric cancer has become a hot topic in recent years. The epigenetics mainly study the changes of gene function and expression level in the case of genetic sequence being unchanged, and its ways mainly include DNA methylation, histone modification and non-coding RNA regulation. Application of epigenetic changes in the diagnosis and prognosis of gastric cancer may be a new direction for the treatment of gastric cancer.
出处
《医学综述》
2017年第10期1919-1922,1928,共5页
Medical Recapitulate
基金
国家自然科学基金(81100045)
