摘要
目的:研究冠心病患者血清中PDGF、Ang-2含量与动脉粥样斑块特征的相关性。方法:收集本院收治的冠心病患者80例作为观察组,同期在本院进行体检的健康人群50例作为正常对照组。检测两组血清中PDGF、Ang-2的含量,其中观察组以PDGF、Ang-2含量中位数进一步分为高PDGF组、低PDGF组,高Ang-2组、低Ang-2组各40例。采用超声造影技术评估冠心病患者的动脉粥样斑块特征。结果:观察组血清中PDGF、Ang-2的含量均显著高于对照组;高PDGF组超声参数P、AUC水平高于低PDGF组,Tp、MTT水平低于低PDGF组;高Ang-2组超声参数P、AUC水平高于低Ang-2组,Tp、MTT水平低于低Ang-2组。结论:冠心病患者血清中PDGF、Ang-2含量增加且与动脉粥样斑块稳定性呈负相关。
Objective： To study the correlation of serum PDGF and Ang-2 contents with atherosclerotic plaque features in patients with coronary heart disease. Methods： A total of 80 patients with coronary heart disease who were treated in our hospital between January 2013 and April 2016 were collected as the observation group, and 50 healthy subjects who received medical examination in our hospital during the same period were selected as the normal control group. Serum PDGF and Ang- 2 contents of two groups of patients were detected, and the observation group were further divided into the high PDGF group and low PDGF group （n =40） as well as the high Ang-2 group and low Ang-2 group （n =40） according to the median of PDGF and Ang-2 contents. Ultrasonic contrast technology was used to assess the atherosclerotic plaque characteristics in patients with coronary heart disease. Results： Serum PDGF and Ang-2 contents of observation group were significantly higher than those of control group; ultrasound parameters P and AUC levels of high PDGF group were higher than those of low PDGF group while Tp and MTT levels were lower than those of low PDGF group; ultrasound parameters P and AUC levels of high Ang-2 group were higher than those of low Ang-2 group while Tp and MTT levels were lower than those of low Ang-2 group. Conclusions： Serum PDGF and Ang-2 contents increase in patients with coronary heart disease and are negatively correlated with the atherosclerotic plaque stability.
出处
《海南医学院学报》
CAS
2017年第8期1041-1043,共3页
Journal of Hainan Medical University
基金
湖北潜江市2010科学技术计划项目(2010012)~~
关键词
冠心病
血小板源性生长因子
血管生成素2
动脉粥样斑块
Coronary heart disease
Platelet-derived growth factor
Angiogenin 2
Atherosclerotic plaque
