摘要
目的甲状旁腺激素(1-34)对空心钉治疗老年股骨颈骨折合并骨质疏松症疗效的观察及分析,为老年股骨颈骨折合并骨质疏松寻找到安全可靠,更具有良好疗效的治疗方案。方法 2010年1月至2016年1月间收治的老年股骨颈骨折合并骨质疏松患者78例,采用随机数字表法将其分为治疗组和对照组,每组39例,两组患者均接受空心钉治疗。治疗患者术后加用甲状旁腺激素治疗,比较两组患者治疗后患者视觉模拟痛疼评分(VAS)、髋关节Harris功能评分、骨折愈合时间及股骨颈及腰椎的骨密度改变。结果术后1、3、6个月两组患者VAS评分均明显降低,且治疗组患者评分明显低于对照组(P<0.05);术后3、6个月两组患者的Harris评分均明显上升,且治疗组患者评分明显高于对照组(P<0.05);治疗组骨折愈合的时间明显少于对照组(P<0.05);术后3、6个月两组患者股骨颈及腰椎的骨密度,治疗组患者骨密度较术前显著改善(P<0.05),而对照组治疗前后上述指标无明显变化(P>0.05)。结论甲状旁腺激素对空心钉治疗老年股骨颈骨折合并骨质疏松症是一种安全、疗效更好的方法。
Objective By observing and analyzing the efficacy of parathyroid hormone（ 1-34） on femoral neck fractures complicated with osteoporosis after cannulated screwsystem treatment in the elderly,to seek a safe,reliable,and more effective treatment for the treatment of femoral neck fractures complicated with osteoporosis in the elderly. Methods Seventy-eight cases of femoral neck fractures were treated from January 2010 to January 2016. They were divided into treatment group and control group by random number table method,with 39 cases in each group. Patients in both groups were treated with cannulated screwsystem. After surgical treatment,the patients in treatment group received parathyroid hormone. The visual analogue pain scores（ VAS）,hip function scores（ Harris）,fracture healing time,and bone mineral density（ BMD） of the femoral neck and lumbar spine were compared between the two groups. Results The VAS scores of the two groups significantly decreased at 1 month,3 months,and6 months after operation,and the score of treatment group was significantly lower than that in the control group（ P 〈 0. 05）. The Harris scores of both groups increased significantly at 3 months and 6months after operation,and the score of treatment group was significantly higher than that in the control group（ P 〈 0. 05）. The BMD of the femoral neck and lumbar vertebrae significantly improved in the treatment group at 3 months and 6 months after operation（ P 〈 0. 05）,but there was no significant change in patients of control group before and after treatment（ P 〉 0. 05）. Conclusion Parathyroid hormone combined with cannulated screwsystem is a safe and effective method for the treatment of femoral neck fractures complicated with osteoporosis in the elderly.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2017年第5期639-642,656,共5页
Chinese Journal of Osteoporosis
基金
安徽省自然科学基金(1708085QH209)
皖南医学院校中青年基金(WK2016F03)
关键词
老年骨质疏松症
骨密度
甲状旁腺激素
空心钉
Osteoporosis in the elderly
Bone mineral density
Parathyroid hormone
Cannulated screw system
