摘要
呼吸道与外界环境相通，长期暴露于各种理化物质及病原微生物刺激之下，其上皮细胞分泌的具有抗菌活性的蛋白对维持机体健康至关重要。短腭、肺及鼻咽上皮克隆1（short palate，lung，and nasal epithelium clone1，SPLUNCl）就是新近发现的一种具有抗菌活性的蛋白，其结构与杀菌／渗透性增加蛋白相似，能特异结合革兰阴性菌细胞壁上的脂多糖，有助于维持内稳态、保持肺内无菌环境，在快速激活先天免疫及启动适应性免疫中起守门员作用，有望作为抗菌制剂用于呼吸道细菌感染性疾病的治疗。
Respiratory tract and the external environment are interlinked,long-term exposure to a variety of physical and chemical substances and pathogenic microorganism stimulation, the antimicrobial activity of proteins secreted by epithelial cells is critical for maintaining health, short palate, lung, and nasal epithelium clone 1 （ SPLUNC1 ） is a lately discovered protein with antthactedal activity. Its structure is similar to the bactericidal permeability-increasing protein（BPI）. SPLUNC1 binds specifically to lipopolysaccharide（ LPS ） of cell walls of gram-negative bacteria, and contributes to maintain homeostasis and a sterile environment in the lung, and acts as a goalkeeper role in the rapid activation of innate immunity and the initiation of adaptive immunity. SPLUNC1 is expected to become an antimicrobial agents for the treatment of respiratory tract bacterial infectious diseases.
出处
《国际儿科学杂志》
2017年第5期312-315,共4页
International Journal of Pediatrics
基金
浙江省自然科学基金资助项目（LZ13H010001）
浙江省教育厅项目（Y201432837）
卫生部国家临床重点专科开放课题（20130209）
温州市2014公益性科技计划项目（Y20140668）
浙江省大学生科技创新活动计划（新苗人才计划）项目（2015R413080）
关键词
短腭、肺及鼻咽上皮克隆1
抗菌肽
炎症
先天性免疫反应
气道上皮细胞
Short palate, lung, and nasal epithelium clone 1
Antimicrobial
Inflammation
Innate immunity
Airway epithelial cell
