摘要
目的:探讨重组人生长激素(rh GH)治疗儿童生长激素缺乏症(GHD)的疗效及对部分相关激素水平的影响。方法:64例GHD患儿作为研究对象给予rh GH 1次/d注射治疗,观察治疗前、治疗6个月及12个月时的身高(Ht)、身高标准差积分(Ht-SDS)、生长速率(GV)、体质指数(BMI)、骨龄/实际年龄比值(BA/CA),治疗3个月、6个月、9个月及12个月时身高增值(ΔHt)、身高标准差积分增值(ΔHt-SDS)及GV等生长指标变化,同时检测治疗前、治疗6个月及12个月时患儿的血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、血清胰岛素样生长因子-1(IGF-1)、血清胰岛素样生长因子结合蛋白-3(IGFBP-3)水平,随访12月并记录患儿的不良反应。结果:与治疗前比较,GHD患儿治疗6个月、12个月时的Ht、Ht-SDS及GV明显升高(P<0.05),但BMI、BA/CA比值与治疗前比较差异无统计学意义(P>0.05),且ΔHt、ΔHt-SDS及GV随着治疗时间的延长均呈下降趋势;治疗6个月、12个月时患儿血清的IGF-1、IGFBP-3及FT3水平均显著高于治疗前,治疗12个月时患儿血清的IGF-1、IGFBP-3水平显著高于治疗6个月时的水平(P<0.05),治疗期间患儿无不良反应。结论:rh GH治疗儿童GHD具有明显的促生长效果,且不会对骨龄成熟、体重产生明显影响,但会对甲状腺激素代谢产生一定影响。
Objective： To investigate the effect of recombinant human growth hormone （rhGH） treat- ment to children with growth hormone deficiency （GHD） and the influence on related hormone levels. Methods： Sixty-four GHD children were recruited and were given rhGH injection once a day （ 0.1 0.15 IU/kg） for 6 months. Their body hight （ Ht）, hight standard deviation integrat （ Ht-SDS）, growth velocity （GV）, body mass index （BMI） , bone age/actual age （BA/CA） were observed before and 6 months and 12 months after the treatment. The increases of Ht, and Ht-SDS, and other GV in-after treatment were not significantly different from those before （P 〉 0.05 ）. The increasing speeds of Ht, Ht-SDS, and GV decreased along with the prolongation of the treatment. The levels of serum IGF- 1, IGFBP-3, and FT3 were significantly increased in 6 months and 12 months after the treatment, and the levels of IGF-1 and IGFBP-3 in 12 months after treatment were significantly higher than those in 6 months（P 〈 0.05）. Conclusions： The rhGH treatment has obvious effect to GHD children in promo- ting growth, and it has not obvious influence on bone age maturation and weight. But it might have an impact on thyroid hormone metabolism
出处
《贵州医科大学学报》
CAS
2017年第5期557-560,565,共5页
Journal of Guizhou Medical University
基金
国家自然科学基金(8156150433)
四川省卫生厅科研项目基金(090079)
关键词
甲状腺激素
生长激素缺乏症
重组人生长激素
儿童
thyroid hormone
growth hormone deficiency
recombinant human growth hormone
children
