摘要
心血管疾病是严重危害人类健康和生命的疾病之一，脂质代谢异常是导致心血管疾病的最重要的危险因素。女性进入围绝经期后，心血管疾病的发病率明显高于育龄期女性。围绝经期女性雌激素水平下降导致脂质代谢紊乱被认为是导致围绝经期女性冠状动脉粥样硬化甚至心血管疾病的主要原因。替勃龙作为组织选择性雌激素活性调节剂联合他汀类药物可以更好地调节脂质代谢，改善围绝经期女性脂质水平。本文围绕围绝经期女性脂质代谢特点、替勃龙替代疗法及其联合他汀类药物调节围绝经期女性血脂代谢的研究和胆固醇代谢标志物对评价围绝经期血脂异常女性脂质代谢状况及其药物疗效的作用作一综述，为实现围绝经期血脂异常女性个体化治疗，延缓冠状动脉病变进展，开展心血管疾病的二级预防工作提供用药依据。
Abnormal lipid metabolism is one of the most important risk factors of cardiovascular diseases. The incidence of cardiovascular diseases in perimeuopausal women is significantly higher that in childbearing age women; perimenopausal lipid metabolism disorder caused by estrogen decreasing is considered to be a main risk of coronary atherosclerosis and cardiovascular diseases. Tibolone, as a tissue selective estrogenic activity regulator, combined with statins can effectively regulate lipid metabolism in perimenopausal women. This article reviewed characteristics of perimeuopausal lipid metabolism and latest findings reg arding tibolone plus statins treating perimenopausal lipid metabolism to provide evidence for individualized treatment of perinlenopausal women with dyslipidemia and secondary prevention of cardiovascular diseases.
出处
《中国医药》
2017年第6期954-957,共4页
China Medicine
基金
北京市卫生和计划生育委员会科研专项（首发2014-2-1053）
关键词
围绝经期
心血管疾病
代谢标志物
调脂治疗
Perimenopause
Cardiovascular diseases
Metabolic markers
Lipid-lowering therapy
