摘要
肠道作为机体与外界相通的器官,起到一个重要的屏障功能。但肠道也极易发生损伤。转化生长因子β(TGF-β)在小肠绒毛中表达丰富。TGF-β/Smads信号通路主要由TGF-βs、TβR和Smads蛋白组成。TGF-β/Smads信号在肠道损伤的产生、发展中起到重要的调控作用。本文介绍了TGF-β/Smads信号通路,并综述了TGF-β在肠黏膜上皮的分布以及其鸡在肠黏膜损伤中的作用。
As an organ which connects body with the outside environment, gut plays an important role in barrier function. Many common poultry diseases may result in the injury to chicken intestinal mucous. Transforming growth factor β （TGF-β） is a kind of necessary epitheli- al growth factor which can improve mncosal repair function. Its relative signaling pathwayTGF-β/Smads also plays an important role in the production and development of intestinal diseases. This paper reviewed TGF-β/Smads signaling pathway and its function in intestinal mucosa injury of chickens.
出处
《畜牧与兽医》
北大核心
2017年第5期166-168,共3页
Animal Husbandry & Veterinary Medicine
基金
NSFC-河南联合基金项目(U1404323)
河南工业大学校基础研究计划项目(2014JCYJ11)
河南工业大学高层次人才基金(150108)
关键词
鸡
肠道疾病
转化生长因子
transforming growth factor
mucosa injury
chicken
