摘要
本研究采用壳聚糖和海藻酸钠作为载体材料,通过离子交联法和超声辅助法制备了吡虫啉的载药微粒。相比较而言,直接的离子交联法直接冷冻干燥的产物制备过程简单,但制得的产物爆释现象明显,2小时内达到了90%的释放量;采用有机溶剂增溶的方法能够将载药量从10mg/g以下提高到26mg/g,采用超声波辅助的方法制得的微粒载药量高,最高的载药量可超过100mg/g,并且稳定性较好;测试了海藻酸钠及其与壳聚糖形成的聚电解质复合物的载药性能,结果显示相对单独的聚电解质微粒载药效果有所提高。
In this study, imidacloprid loaded nanoparticles were prepared through ionic gelation and ultrasonic method, using chitosan and sodium alginate as carrier material. Products prepared by ionic gelation showed burst release of 90% in the first 2 hours, the loading capacity was improved from lOmg/g to 26mg/g with the organic sol- vent solubilization, products prepared by ultrasonic method showed higher loading capacity of 80mg/g and better stablity, loading capacity of sodium alginate/chitosan polyelectrolyte complex was tested, complex nanoparticles showed higher loading capacity than single polyelectrolyte nanoparticles.
出处
《造纸科学与技术》
2017年第2期30-34,共5页
Paper Science & Technology
基金
国家自然科学基金项目(31200457)
关键词
壳聚糖
离子交联
载药微粒
吡虫啉
chitosan
ionic gelation
drug loading
imidacloprid
