摘要
目的 观察中药自拟方联合米非司酮治疗子宫肌瘤的疗效及对患者性激素水平的影响.方法将100例子宫肌瘤的患者按随机数字表分为对照组和治疗组,每组各50例.对照组给予米非司酮治疗,治疗组在对照组用药基础上加服自拟汤药治疗,两组疗程均为3个月,治疗前后比较两组患者性激素水平、症状体征积分等相关指标,进行临床疗效评估.结果 两组临床疗比较,治疗组总有效率为84%,对照组总有效率为66%,治疗组的临床疗效明显高于对照组,差异有统计学意义（x2=9.88,P＜0.05）;与治疗前[对照组LH：（57.2±9.6）U/L,E2：（17.9±6.9）pmol/L,FSF：（32.7±8.5）g/L,P：（17.5±5.2）nmol/L;治疗组黄体生成素（LH）：（56.7±10.2）U/L,雌二醇（E2）：（17.3±7.9）pmol/L,促卵泡激素（FSF）：（33.5±7.9）g/L,孕酮（P）：（18.4±3.2）nmol/L]比较,两组治疗后的性激素水平[对照组LH：（47.5±8.3）U/L,E2：（12.5±3.8）pmol/L,FSF：（18.3±6.9）g/L,P：（14.8±3.2）nmol/L;治疗组LH：（38.7±8.1）U/L,E2：（7.5±4.3）pmol/L,FSF：（10.2±5.2）g/L,P：（10.5±4.8）nmol/L]明显降低,差异有统计学意义（P＜0.05）.结论 自拟汤药联合米非司酮对治疗子宫肌瘤有良好的临床疗效,能够通过提高机体的免疫力,降低体内性激素水平,抑制平滑肌组织增生,缩小肌瘤,改善临床症状,值得推广.
Objective To observe the curative effect of Chinese herbal medicine decoction combined with mifepristone in the treatment of uterine fibroids and the effects on hormone levels.Methods 100 patients with uterine fibroids were divided into the treatment group and control group according to random number table, 50 cases in each group.The treatment group was given the liquid form joint mifepristone, the control group was given mifepristone.The two groups were treated for a course of 3 months.The sex hormone levels before and after treatment, the symptoms and signs integral related indicators were compared.The clinical efficacy was evaluated.Results The total effective rate of the treatment group was 84%, which was obviously higher than 66% of the control group （x2=9.88,P〈0.05）.Compared with before treatment[the control group,LH：（57.2±9.6）U/L,E2：（17.9±6.9）pmol/L,FSF：（32.7±8.5）g/L,P：（17.5±5.2）nmol/L;the treatment group,LH：（56.7±10.2）U/L,E2：（17.3±7.9）pmol/L,FSF：（33.5±7.9）g/L,P：（18.4±3.2）nmol/L], after treatment the levels of sex hormones in the two groups significantly reduced[the control group,LH：（47.5±8.3）U/L,E2：（12.5±3.8）pmol/L,FSF：（18.3±6.9）g/L,P：（14.8±3.2）nmol/L;the treatment group,LH：（38.7±8.1）U/L,E2：（7.5±4.3）pmol/L,FSF：（10.2±5.2）g/L,P：（10.5±4.8）nmol/L],the differences were statistically significant（all P〈0.05）.Conclusion Chinese herbal medicine decoction combined with mifepristone in the treatment of uterine fibroids has good clinical curative effect, by increasing the body＇s immunity, lowering levels of sex hormones in the body, inhibition of smooth muscle tissue, thus to narrow the myoma, improve clinical symptoms, it is worthy of promoting.
出处
《中国基层医药》
CAS
2017年第11期1670-1673,共4页
Chinese Journal of Primary Medicine and Pharmacy
