摘要
目的:运用血氧水平依赖磁共振成像(BOLD MRI)序列评估肾动脉狭窄患者肾脏氧合状态,分析患者肾脏R2*值与健康人R2*值及自身肾动脉狭窄程度之间的关系。方法:使用西门子3.0T磁共振机对28例肾动脉狭窄患者及16例健康志愿者的肾脏进行BOLD扫描,所得图像通过西门子工作站及MATLAB软件进行处理分析、手动勾画感兴趣区,得到R2*值,进行分析比较。结果:正常健康人肾髓质R2*值(29.61±2.26)高于皮质(18.23±1.77),肾脏上、中、下部R2*值差异无统计学意义。肾动脉狭窄患者肾皮质、髓质R2*值(21.14±4.90);(36.25±8.04)均较正常人有显著增高,其差异具有统计学意义(P<0.05),且髓质变化更为敏感。在患者组各亚组中,肾动脉重度狭窄患者肾髓质R2*值(44.20±6.01)较其他各亚组明显增高,差异具有统计学意义(P<0.05),而肾动脉重度狭窄患者肾皮质R2*值(24.06±5.94)仅显著高于无明显狭窄组(18.96±3.62)(P<0.05),与轻、中度狭窄患者(20.20±2.01);(19.14±1.86)并差异无统计学意义。分别对患者组皮质和髓质R2*值与所对应一侧肾脏肾小球滤过率进行相关性分析,未发现有显著的相关性。结论:BOLD MRI序列是一种有效的无创性评估肾脏氧合状态的检查方法,在肾动脉狭窄程度的判断上具有一定的意义和作用,而且是检测肾髓质缺血缺氧的敏感手段。
Objective：The purpose of this article is comparing R2＊ value in renal artery stenosis pa- tients with R2＂ value in control groups and the degree of renal artery stenosis of its own by blood oxygen level- dependent （BOLD） magnetic resonance imaging （MRI）. Methods：28 patients with renal artery stenosis and 16 healthy volunteers received renal BOLD MRI examination On Siemens 3.0T scanner. Post-process and analy- sis were performed on Siemens workstation and Matlab. R2 ＊ value （1/sec） of cortex and medulla were recor- ded and analyzed respectively. Results ： Medulla R2 ＊ value was higher than cortex R2 ＊ value in control group. No significant difference in R2 ＊ value was found in different parts （upper, middle, lower part） of kidneys. Both cortex and medulla R2 ＊ value in renal artery stenosis patients （ 21.14 ± 4. 90 ） ; （ 36. 25 ± 8.04 ） were higher than corresponding R2 ＊ value in control group with a significant gap （ P 〈 0.05 ） , and a more sensitive change in medulla R2 ＊ value was found. Among different subgroups in patient group, medulla R2 ＊ value in se- vere stenosis group（44. 20 ± 6. 01 ） was higher than other subgroups （ P 〈 0.05 ）, but cortex R2 ＊ value in se- vere stenosis group （ 24. 06 ± 5.94 ） was found no significant difference from mild stenosis, moderate stenosis subgroups （20. 20 ±2.01 ） ; （ 19. 14 ± 1.86） while it was higher than unobstructed subgroup（ 18. 96 ± 3.62）（ P 〈 0.05 ）. No correlation was found between R2 ＊ value and glomerular filtration rate of the same kidney in cortex or medulla. Conclusion：BOLD MRI is an effective and noninvasive method to evaluate the oxygenation state of kidney. It can play an important role in estimation of stenosis degree of renal artery. BOLD MRI is a sensitive tool which can be used to detect ischemia and anoxia of medulla of kidney.
出处
《心肺血管病杂志》
2017年第4期293-296,303,共5页
Journal of Cardiovascular and Pulmonary Diseases
关键词
血氧水平依赖
肾动脉狭窄
磁共振成像
Blood oxygen level-dependent
Renal artery stenosis
Magnetic Resonance Imaging
