摘要
目的:探究燕麦多肽对小鼠体内降血糖的功能。方法:实验采用ICR小鼠进行糖尿病造模,对燕麦多肽干预后小鼠的降血糖相关指标进行了研究。将90只雌性ICR小鼠随机分为6组,正常对照组、模型组、阳性组(二甲双胍0.6 g/kg)和燕麦多肽高、中、低剂量组(燕麦多肽1、0.5、0.25 g/kg),连续灌胃28 d。并对小鼠的体重、饮食、饮水、血糖水平、胰岛素含量和肝糖原含量进行测定。结果:燕麦多肽组小鼠体重缓慢增加,与模型组相比,燕麦多肽高剂量组从第2周开始进食量显著降低(p<0.05),第3周开始饮水量显著降低(p<0.05),高剂量组小鼠血糖在给药后第2~4周极显著降低(p<0.01),中剂量组小鼠血糖在给药后第3~4周极显著降低(p<0.01),且4周后中、高剂量组肝糖原含量显著提高(p<0.05),高剂量组胰岛素含量显著提高(p<0.05)。结论:燕麦多肽可增加糖尿病小鼠体重,改善其多饮多食的症状。
Objective： To investigate the hypoglycemic effect of oat peptides in rats. Methods：In this research, hypnglycemie functions of oat peptides were studied in vivo. Using the ICR diabetes mice, hypoglyeemic related indicators after peptides intervention were tested.90 female ICR rices were divided into six groups randomly：nomal control group,model group（ DMBG 0.6 g/kg）, lowdose oat peptides group （ oat peptides 0.25 g/kg）, mediumdose oat peptides group （ oat peptides 0.5 g/kg）. high-dose oat peptides group（oat peptides 1 g/kg） ,continuous filling stomach fnr 28 days.The level of weight,diet, drinking water,blood glucose,insulin and liver glycogen were measured.Results：The weight of mice in the oat peptides groups were all increased slowly.Compared with the model group, the food-intake in the high-dose oat peptides group were significantly induced from the second week（p 〈 0.05 ） , and the water consumption in the high-dose oat peptides group were significantly induced from the thind week （p 〈 0.05 ） , blood sugar was significantly decreased from the second week to tburth week （p 〈 0.01 ）and frmn the third week to fourth week in the medium-dose group（p 〈0.01 ）.At the end of the fourth week mice in the high-dose and medium-dose group,its hepatic glycogen content were significantly increased（p 〈 0.05 ） , and insulin level were significantly improved in the high- dose group （ p 〈 0.05 ） . Conclusion ： Oat peptides could increase mice body weight, and improve its diabetes symptoms of food intake.
出处
《食品工业科技》
CAS
CSCD
北大核心
2017年第10期360-363,384,共5页
Science and Technology of Food Industry
基金
国家自然科学基金项目(31401522)
北京市教育委员会面上项目(KM201510011006)
关键词
燕麦
多肽
降血糖
oat
peptides
hypoglycemic
