摘要
目的对照研究阿立哌唑与齐拉西酮对女性精神分裂症患者催乳素的影响。方法选择2014年10月~2016年10月收治的80例女性精神分裂症患者作为研究对象,均分为两组:对照组(40例)给予阿立哌唑治疗,研究组(40例)给予齐拉西酮治疗。分析对比两组治疗前、治疗1个月、3个月、6个月催乳素水平变化以及PANSS、BPRS、SANS评分变化。结果 (1)治疗前,两组PANSS、BPRS、SANS评分差异无统计学意义(P>0.05)。治疗后,两组PANSS、BPRS、SANS评分均有变化,但组间数据差异无统计学意义(P>0.05)。(2)治疗前,两组催乳素水平差异无统计学意义(P>0.05)。治疗1个月、3个月、6个月后两组催乳素水平均发生了变化,但研究组催乳素水平低于对照组,差异有统计学意义(P<0.05)。结论阿立哌唑、齐拉西酮在治疗女性精神分裂症方面效果相当,但齐拉西酮对患者催乳素水平影响较小,可作为治疗的首选药物。
Objective To contrast the impact of prolactin of aripirazole and ziprasidone in female patients with schizophrenia. Methods Selected 80 cases of female patients with schizophrenia from Oct 2014 to Oct 2016 and di-vided into two groups control group（40 cases） with aripiprazole treatment, research group （40 cases） with ziprasidone treatment. Compared the two groups before treatment, 1 month,3 months,6 months after treatment prolactin levels and PANSS,BPRS,SANS score changes.Results Before treatment,PANSS,BPRS,SANS score in two groups had no signifi-cant differences（P〉0.05）.After treatment,PANSS,BPRS,SANS score of two groups had changes,but data had no signif-icant differences between groups（P〉0.05）.Before treatment, prolactin levels of two groups had no significant differences （P〉0.05）.Prolactin levels of two grous 1 month,3 months,6 months after treatment changed,but the prolactin level of research group was lower than control group （P〈0.05）. Conclusion Aripiprazole and ziprasidone in the treatment of fe-male schizophrenia have the quite effective, but ziprasidone’s influence on patients with prolactin is less, it can be used as the first choice for treatment.
作者
吴志杰
马淑君
陈耿谊
Wu Zhijie Ma Shujun Chen Gengyi(The Fourth People＇s Hospital of Shantoug Shantou 515021)
出处
《中国现代医药杂志》
2017年第5期28-30,共3页
Modern Medicine Journal of China
