摘要
目的探讨分析应用前列地尔联合羟苯磺酸钙治疗糖尿病肾病患者的临床疗效。方法将我院2013年1月—2016年9月收入院进行治疗的糖尿病肾病患者60例纳入研究,将60例患者随机分为观察组和对照组,每组各30例,对照组患者采用前列地尔药进行物治疗,观察组患者在对照组的治疗基础上联合羟苯磺酸钙药物治疗,治疗12周,记录观察指标变化情况,评价其临床疗效。结果根据制定的标准,治疗后观察组的临床有效率为93.3%,对照组的临床有效率为76.7%,差异具有统计学意义;治疗后两组患者的24 h尿蛋白定量、血肌酐(Cr)、尿素氮(BUN)指标均有下降,观察组患者的3项指标分别为(0.53±0.47)g、(103.25±28.13)μmol/L、(6.42±2.17)mmol/L,对照组患者的指标分别为(1.31±0.39)g、(132.57±27.26)μmol/L、(9.78±2.47)mmol/L,两组对比,观察组低于对照组,差异具有统计学意义。结论前列地尔联合羟苯磺酸钙治疗糖尿病肾病相对于前列地尔药物单用临床有效率高,对临床指标改善效果明显。
Objective To investigate and analyze the clinical efficacy of alprostadil combined with calcium dobesilate in the treatment of diabetic nephropathy. Methods in our hospital from January 2013 to September 2016 the income of hospital for treatment of 60 cases of diabetic nephropathy were included in the study, 60 patients were randomly divided into observation group and control group, 30 cases in each group, control treatment with alprostadil treatment group patients, patients in the observation group in the control group based on the combined treatment of calcium dobesilate drug therapy, treatment for 12 weeks, observed changes of the index, to evaluate its clinical efficacy. Results According to the established standard, the clinical effective rate was 93.3% in the observation group and 76.7% in the control group. The difference was statistically significant. The levels of 24 h urinary protein quantitation, serum creatinine （Cr） and urea nitrogen （BUN） were decreased in the two groups after treatment. The three indexes of the observation group were （0.53±0.47） g, （103.25±28.13） μmol/L, （6.42±2.17）mmol/L, the mean value of the patients the control group was （1.31±0.39） g, （132.57±27.26） μmol/L, （9.78±2.47） mmol/L, the two groups were significantly lower than the control group, the difference was statistically significant. Conclusion Alprostadil combined with calcium dobesilate is more effective in the treatment of diabetic nephropathy than alprostadil, and has a significant effect on the improvement of clinical indexes.
作者
曹伟波
CAO Weibo(Nephrology Department, Dongchangfu People＇s Hospital of Liaoeheng, Liaocheng Shandong 252000, Chin)
出处
《中国继续医学教育》
2017年第9期98-100,共3页
China Continuing Medical Education
关键词
糖尿病肾病
临床治疗
前列地尔
羟苯磺酸钙
diabetic nephropathy
clinical treatment
alprostadil
calcium dobesilate
