摘要
目的观察噻托溴铵联合福莫特罗治疗老年慢性阻塞性肺疾病的临床疗效。方法 60例慢性阻塞性肺疾病老年患者,应用信封法随机分为试验组与对照组,各30例。对照组应用福莫特罗吸入治疗,试验组应用噻托溴铵联合福莫特罗吸入治疗。比较两组患者治疗前后肺功能变化情况。结果治疗前,两组患者肺功能水平比较差异无统计学意义(P>0.05);治疗后,试验组患者第一秒用力呼气容积(FEV1)为(1.65±0.46)L、FEV1占预计值的百分比(FEV1%)为(70.15±9.87)%,均高于对照组的(1.41±0.39)L、(62.84±10.83)%,差异均具有统计学意义(P<0.05)。结论老年慢性阻塞性肺疾病患者通过应用噻托溴铵联合福莫特罗治疗,可有改善低肺内炎性表现,有效恢复患者肺功能水平,提高临床疗效,控制病情,降低耐药性,临床疗效优异,值得临床推广。
Objective To observe clinical effect by tiotropium bromide combined with formoterol in the treatment of senile chronic obstructive pulmonary disease. Methods A total of 60 senile chronic obstructive pulmonary disease patients were randomly divided by envelop method into experimental group and control group, with 30 cases in each group. The control group received inhalation of formoterol for treatment, and the experimental group received inhalation of tiotropium bromide combined with formoterol for treatment. Comparison was made on changes in pulmonary function before and after treatment between the two groups. Results Before treatment, there was no statistically significant difference of pulmonary function level between the two groups（P〉0.05）. After treatment, the experimental group had forced expiratory volume in 1 second（FEV1） as（1.65±0.46） L and FEV1 percentage of expected value（FEV1%） as（70.15±9.87）%, which were all higher than（1.41±0.39） L and（62.84±10.83） % in the control group, and their difference all had statistical significance（P〈0.05）. Conclusion Application of tiotropium bromide combined with formoterol in the treatment of senile chronic obstructive pulmonary disease can effectively improve pulmonary inflammatory manifestations, recover pulmonary function level, improve clinical effect, control disease condition and lower drug resistance. This method shows excellent clinical effect, and it is worth clinical promotion.
出处
《中国实用医药》
2017年第10期111-113,共3页
China Practical Medicine
关键词
老年慢性阻塞性肺疾病
噻托溴铵
福莫特罗
Senile chronic obstructive pulmonary disease
Tiotropium bromide
Formoterol
