摘要
本文以普梭草素为先导化合物,设计和合成了以吖啶酮环为母核,含有环氧乙烷侧链作为烷基化官能团的目标化合物,其结构经质谱、核磁共振氢谱和碳谱确证。在体外抗肿瘤活性测试中,目标产物表现出较强的细胞毒活性。
Using psorospermin as a lead, 2 target compounds were designed and synthesized bearing acridone ring and oxirane moiety as alkylating group. The structures were confirmed by MS, 1H and 13C NMR. The final products exhibited potent cytotoxicity in the in vitro MTT assay.
出处
《广东化工》
CAS
2017年第9期18-18,22,共2页
Guangdong Chemical Industry
基金
江西省卫计委中医药科技计划项目(2015A046
2016A013)
关键词
普梭草素
吖啶酮
合成
抗肿瘤活性
psorospermin
acridone
synthesis
anticanceractivity
