摘要
目的探讨复方益肝灵胶囊对预防抗结核药物所致的肝损害的疗效。方法选取我院2014年7月至2016年6月期间收治的120例肺结核患者,随机分为对照组和研究组各60例。两组均给予常规抗结核药物治疗,在此基础上,对照组给予葡醛内酯,研究组给予复方益肝灵胶囊。结果治疗4周后,研究组的临床症状发生率为11.67%,明显低于对照组的28.33%(P<0.05)。治疗结束后,两组患者的临床症状均得到有效控制,临床症状发生率比较差异无统计学意义(P>0.05)。研究组治疗4周后与治疗结束后的肝功能指标均明显优于对照组(P<0.05)。研究组的肝功能受损率和中断治疗率均明显低于对照组(P<0.05)。结论复方益肝灵胶囊能够有效预防抗结核药物所致的肝损害,促进患者的预后。
Objective To explore the curative effect of compound silybin capsules in the prevention of liver damages caused by anti-tuberculosis drugs. Methods 120 cases of patients with tuberculosis admitted to our hospital fi＇om July 2014 to June 2016 were selected and divided into control group and study group, with 60 cases in each group. Both groups were treated with conventional anti-tuberculosis drugs. On this basis, the control group received glucurolactone, and the study group received compound silybin capsules. Results After 4-week treatment, the incidence of clinical symptoms of study group was 11.67%, significantly lower than 28.33% of control group （P〈0.05）. At the end of the treatment, the clinical symptoms of both groups were effectively controlled, but had no statistical difference in the incidence of clinical symptoms between two groups （P〉0.05）. The indicators of liver function after 4-week treatment and at the end of the treatment of study group were significantly better than those of control group （P〈0.05）. The liver function damage rate and treatment interruption rate of study group were significantly lower than those of control group （P〈0.05）. Conclusions Compound silybin capsules can effectively prevent the liver damages caused by anti-tuberculosis drugs and promote patients＇ prognosis.
出处
《临床医学工程》
2017年第5期697-698,共2页
Clinical Medicine & Engineering
关键词
肝损害
抗结核药物
复方益肝灵胶囊
Liver damages
Anti-tuberculosis drugs
Compound silybin capsules
