摘要
目的探讨特应性体质肺炎支原体（MP）肺炎患儿的临床特点及血清白细胞介素－17（IL－17）的水平。方法选择2015年10月至2016年12月天津市南开医院儿科住院的162例MP肺炎患儿分为2组：特应性组（特应性体质MP肺炎患儿）50例，非特应性组（非特应性体质MP肺炎患儿）112例；选择同期本院儿科门诊健康体检的30例儿童为健康对照组，分析2组MP肺炎患儿的临床及实验室检查特点，同时用酶联免疫吸附法检测2组MP肺炎患儿血清IL－17水平。结果特应性组患儿病情重，吸氧治疗例数、糖皮质激素治疗例数、糖皮质激素治疗天数及既往哮喘病史均多于非特应性组，2组比较差异均有统计学意义（均P〈0.05）。特应性组患儿血清总免疫球蛋白E[230.5（120.8，421.5） IU/mL]明显高于非特应性组患儿[79.9（46.1，125.3） IU/mL]，血清乳酸脱氢酶（LDH）[（319.3±118.9） IU/L]明显高于非特应性组患儿[（255.5±66.6） IU/L]，2组比较差异均有统计学意义（均P〈0.01）。健康对照组、特应性组及非特应性组儿童血清IL－17水平分别为（60.2±15.7） ng/L、（382.2±181.7） ng/L和（532.3±169.1） ng/L, 3组比较差异有统计学意义（F＝105.668，P＝0.000），而特应性组患儿血清IL－17低于非特应性组患儿，2组比较差异有统计学意义（t＝－3.861，P〈0.01）。结论特应性体质可能对MP肺炎产生不利影响，这可能与体内低水平的IL－17有关。
ObjectiveTo explore the clinical characteristics and the levels of interleukin-17 （IL-17） in Mycoplasma pneumoniae （MP） pneumonia patients with atopic sensitization.MethodsOne hundred and sixty-two patients with MP pneumonia were hospitalized at the Department of Pediatrics, Tianjin Nankai Hospital from October 2015 to December 2016.All children with MP pneumonia were evaluated and divided into 2 groups： the atopic group （atopic MP pneumonia children, n=50） and the non-atopic group （non-atopic MP pneumonia children, n=112）. Furthermore, 30 healthy children were also included in this study as healthy control group at the Department of Pedia-trics, Tianjin Nankai Hospital at the same time.The clinical characteristics and laboratory data of MP pneumonia patients of 2 groups were recorded and analyzed.The levels of serum IL-17 of MP pneumonia patients were measured by using enzyme-linked immunosorbent assays.ResultsChildren with atopic MP pneumonia had more severe pneumonia.At the same time, the number of cases of oxygen therapy and glucocorticoid treatment, the duration of glucocorticoid treatment and the history of previous asthma in the atopic group were higher than those in the non-atopic group, and there was statistical difference between 2 groups（all P〈0.05）. The level of serum total immunoglobulin E in the atopic group [230.5（120.8, 421.5） IU/mL] was higher than that in the non-atopic group [79.9（46.1, 125.3） IU/mL], and the level of serum lactate dehydrogenase（LDH）in the atopic group [（319.3±118.9） IU/L] was higher than that in the non-atopic group [（255.5±66.6） IU/L], and there were statistical differences between 2 groups（ all P〈0.01）. The levels of serum IL-17 in the healthy control group, atopic group and non-atopic group were（60.2±15.7） ng/L, （382.2±181.7） ng/L and（532.3±169.1） ng/L, respectively, and there were statistical differences among the 3 groups（F=105.668, P=0.000）. Whereas, the level of serum IL-17 in the atopic group was lo
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2017年第9期668-671,共4页
Chinese Journal of Applied Clinical Pediatrics
基金
天津市卫生局科技项目（2014KZ049）
