摘要
目的 探讨中青年非肥胖型非酒精性脂肪肝（NAFLD）患者的临床特征.方法 选取我院中青年非酒精性脂肪肝患者120例,根据BMI分为两组：非肥胖型（18.5kg/m2≤BMI〈24kg/m2）NAFLD患者为NAFLD 1组（58例）,肥胖型（BMI≥24kg/m2）NAFLD患者为NAFLD 2组（62例）,另以96例健康者作为对照组,比较分析3组间临床指标,采用Logistic回归分析相关危险因素.结果（1）NAFLD1组的ALT、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）高于正常组,高密度脂蛋白胆固醇（HDL-C）低于正常组,差异有统计学意义（P〈0.05）,余指标差异无统计学意义;NAFLD 2组BMI、腰围、臀围、腰臀比（WHR）、AST、尿酸（UA）、ALT、TG、TC、LDL-C高于正常组,HDL-C低于正常组,差异有统计学意义（P〈0.05）,余指标差异无统计学意义（P〉0.05）;NAFLD 1组BMI、腰围、臀围、WHR低于NAFLD 2组（P〈0.05）,余指标之间差异无统计学意义.（2）采用二分类Logistic行回归分析,显示NAFLD的危险因素为ALT（OR=1.11,95%CI 1.043-1.182）,LDL-C（OR=9.507,95%CI 2.790-32.397）.（3）Pearson相关性分析结果显示,中青年非肥胖型NAFLD的发生与ALT、TG、TC、LDL-C呈正相关,与HDL-C呈负相关.（4）ALT和LDL-C预测非肥胖型NAFLD的受试者工作特征（ROC）曲线显示,ALT曲线下面积（AUC）为0.86;LDL-C的AUC为0.84.结论 中青年非肥胖型NAFLD患者的皮下脂肪量明显低于肥胖患者,但代谢综合征特点明显,提示控制体重、调脂等对减轻非肥胖型NAFLD可能有一定效果.
Objective To study the clinical characteristics of nonobese nonalcoholic fatty liver disease（NAFLD） in young and middle-aged patients.Methods A total of 120 young and middle-aged patients with nonobese NAFLD were divided into two groups according to the baseline BMI：NAFLD 1 group（nonobese group,18.5kg/m2≤BMI〈24kg/m2,58 cases） and NAFLD2 group（obese group,BMI≥24kg/m2,62 cases）.The control group（96 cases） was composed of the healthy people.Compare and analyze clinical indexes of three groups total.Risk factors were analyzed by Logistic regression.Results （1）NAFLD1 group was higher than control group in ALT,total triglyceride（TG）,cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,lower in high density lipoprotein cholesterol（HDL-C）（P〈0.05）,other indicators were no evident differences.NAFLD 2 group was higher than control group in waist circumference,hip circumference,waist-to-hip ratio（WHR）,AST,uric acid（UA）,ALT,TG,TC,LDL-C,lower in HDL-C（P〈0.05）,other indicators were not significantly different.NAFLD2 group was higher than NAFLD1 group in waist circumference,hip circumference and WHR（P〈0.05）,other indicators were not significantly different.（2）Binary Logistic regression analysis showed that ALT（OR=1.11,95%CI 1.043-1.182）and LDL-C（OR=9.507,95%CI 2.79-32.397） were risk factors.（3）Pearson correlation analysis revealed positive correlation between ALT,TG,TC,LDL-C and the occurrence of nonobese NAFLD,negative correlation between HDL-C and nonobese NAFLD.（4）The area under curve（AUC） of ALT and LDL-C were 0.86 and 0.84.Conclusion Young and middle-aged nonobes NAFLD patients were thinner and had less subcutaneous fat than the fat people while nonobese NAFLD patients behave severe metabolic syndrome,and it,s good for nonobese NAFLD patients to control weight and blood lipid.
出处
《临床内科杂志》
CAS
2017年第4期258-260,共3页
Journal of Clinical Internal Medicine
关键词
非肥胖型非酒精性脂肪肝
肥胖
代谢综合征
Nonobese nonalcoholic fatty liver disease
Obesity
Metabolic syndrome
