摘要
目的系统评价IL-17 rs3748067基因多态性与胃癌易感性的关系。方法通过检索Pub Med、EMbase、Cochrane Library、CBM、CNKI、万方数据库、维普数据库,筛选多项IL-17基因C>T多态性位点rs3748067与胃癌的易感性相关病例-对照研究,检索时限均为建库至2016年4月20日。通过筛选文献、从中提取数据并进行文献质量评价后,采用Review Manager5.3软件进行Meta分析。结果最终纳入7个病例-对照研究,合计病例组2211例,对照组2698例。Meta分析后结果显示:IL-17基因rs3748067位点(C>T)多态性等位基因模型Tvs C(OR=1.21,95%CI:0.84~1.75,P>0.05),显性模型CT+CCvs TT(OR=1.03,95%CI:0.70~1.52,P>0.05),隐性模型CCvs CT+TT(OR=0.97,95%CI:0.66~1.43,P>0.05),加性模型TTvs CC(OR=1.19,95%CI:0.63~2.25),共显性模型TCvs TT+CC(OR=1.15,95%CI:0.98~1.34,P>0.05),该位点各基因模型均与罹患胃癌的风险无相关性(P<0.05),Hp阳性患者亚组分析结果显示等位基因模型、隐性模型及加性模型均与胃癌的发病呈正相关。结论 Hp阳性胃癌患者中IL-17rs3748067基因等位基因模型、隐性模型及加性模型均与胃癌的发病呈正相关。
Objective To investigate the association between rs3748067 site polymorphism of IL-17 gene and the susceptibity of gastric cancer. Methods The case-control studies on relationship between the IL-17 rs3748067 C〉T polymorphism and gastric cancer susceptibility were collected by searching following databases： PubMed,EMbase,Cochrane Library,CNKI,WanFang Data and VIP from inception to March 2016. After literature screening,data extraction and quality assessment,then meta-analysis was performed by Revman 5.3 soft ware. Results To taled 7 case-control studies finally were chosen in which included 2211 patients in case group and 2698 subjects in control group. Meta-analysis results showed that among the rs3748067 site polymorphisms of IL- 17 gene,the susceptibility of gastric cancer had no obvious change under any model type of them. But,in a subgroup investigation,authors found that allele model,recessive gene model and additive gene model all had positive correlation with the incidence of gastric cancer. Conclusion Allele model,recessive gene model and additive gene model of IL-17 rs3748067 polymorphism are positively related to gastric cancer susceptibility in Hp positive patients.
出处
《实用医药杂志》
2017年第5期392-396,共5页
Practical Journal of Medicine & Pharmacy
基金
国家自然科学基金(81660744)
