摘要
目的:观察康肾口服液治疗慢性肾炎的临床疗效。方法:将300例慢性肾炎患者随机分为对照组1、对照组2和治疗组各100例。对照组1口服贝那普利治疗,每次10 mg,日1次。对照组2口服尿毒清颗粒治疗,每次5 g,日3次,3组均给予低盐低磷优质低蛋白饮食及对症支持治疗。所有患者均行定期随访,每2个月进行电话随访一次,每3个月门诊随访一次,随访内容包括症状、体征,如血压、水肿等症状,并检测24 h尿蛋白定量、尿常规、血肌酐、血尿素氮变化情况。结果:治疗组有效率为97.0%,对照组1有效率为71.0%,对照组2有效率为70.0%;3组治疗后24 h尿蛋白定量、血肌酐及血尿素氮水平比较治疗前均有所减少,比较差异有统计学意义(P<0.01);平均随访时间为(23.01±7.84)个月。随访期间未出现死亡及明显药物不良反应。结论:康肾口服液能显著改善慢性肾炎患者乏力、肿胀等临床症状,疗效显著。
Objective： To observe tile clinical effects of Kangshen Oral I,iquid on chronic nephritis （CN）. Methods： Totally 300 patients with CN were rundomized inlu control group 1 , control group 2 and treatment group, with 100 eases in each group. Con- trol group 1 were given oral administration of Benazepril of 10 rag, once a day; control group 2 were given oral treatment of Niaoduqing Granules of 5 g, three limes a day; the three groups were given low salt, low phosphorus and high quality of low-pro- tein diet and symptomatic md supportive treatment. All the patients were conducted fbllow-up treatment, telephone follow-up once every two months and clinic follow-up every three months. The follow-up contents included symptoms and signs su＇h as blood pressure, edema. The changes of urine protein quantitation, urine routines, set＇urn creatinine and blood urea nitrogen uf 24 h were detected. Results： The effective rate was 97.0% in treatment group, 71.0c in control group 2 and 70.0 in conlrol group 2. The levels of urine protein quautitation, serum creatinine and blood urea nitrngen of 24 h in three groups deeliued alier the treatment; the difference had statistical significance （P 〈 0.01 ）. The duration of average follow-up visit is （23.01 ±7.84 month. During the follow-up, no death or obvious adverse reactions appeared. Conclusion： Kangshen Oral Liquid can significant- ly improve the clinical symptoms of fatigue and edeum due to CN.
出处
《河南中医》
2017年第5期836-838,共3页
Henan Traditional Chinese Medicine
基金
河南省科技发展计划项目(编号:092102310202)
关键词
慢性肾炎
康肾口服液
尿毒清颗粒
贝那普利
chronic nephritis （ CN ）
Kangshen Oral Liquid
Niaoduqing Granules
Benazepril
