摘要
激活素(ACT)A是由抑制素β-A基因编码的同源二聚体蛋白,属于转化生长因子β超家族,在不同种族内具有高度保守性,可通过ACT受体介导信号转导诱发血管生成、炎症反应、免疫反应和胎盘形成从而介导细胞的增殖、分化、凋亡。ACT A对生殖内分泌肿瘤如卵巢癌、前列腺癌、肾上腺癌等有重要影响,此外对其他非内分泌肿瘤的发生、发展也有一定作用。该文总结及深入研究ACT A的作用机制,以期对相关恶性肿瘤患者的诊断、治疗提供新思路。
Activin（ACT） A is a homologous dimeric protein encoded by inhibinβ-A gene, belonging to the transfor- ming growth factor-β, highly conservative in different races. Through angiogenesis,inflammation, immune response, and pla- cental, ACT A mediates cell proliferation, differentiation and apoptosis. Many studies have confirmed ACT A has a certain effect on the occurrence and development of reproductive endocrine tumors, such as ovarian cancer, prostate cancer, adrenal carcinoma, besides,it also plays a role in the occurrence and development of other non-endocrine tumor. Here is to summa- rize and further study the mechanism of ACT A ,with the hope to provide new ideas for the diagnosis and treatment of related malignant tumors.
出处
《医学综述》
2017年第9期1728-1731,1736,共5页
Medical Recapitulate
基金
福建省自然科学基金(2014J01393)
