摘要
目的探讨血清腺苷脱氨酶(ADA)水平与系统性红斑狼疮(SLE)疾病活动度的相关性。方法收集确诊的SLE住院患者(57例)的血清标本,并选取同时期体检的健康成人血清标本(57例)作为对照,检测血清标本中ADA活性并对SLE患者的病历资料进行回顾性分析,以SLE活动指数(SLEDIA)作为判断疾病活动程度的标准,将患者分为3组:缓解组(SLEDAI:0~4分),轻度活动组(SLEDIA:5~9分),中重度活动组(SLEDIA≥10分),分析SLE患者血清ADA活性与疾病活动程度的相关性。同时通过回顾性研究记录SLE患者的红细胞沉降率(ESR)和高敏C-反应蛋白(hs-CRP)并分析二者与患者疾病活动程度的相关性。结果 SLE患者和对照组血清中的ADA活性水平均值分别为(14.58±6.50)U/L和(8.26±2.05)U/L,两组比较差异有统计学意义(P<0.05)。缓解组SLE患者血清中的ADA活性均值为(10.94±5.27)U/L,轻度活动组SLE患者血清中的ADA活性均值为(13.69±4.36)U/L,中重度活动组SLE患者血清中的ADA活性均值为(17.75±7.09)U/L,组间差异有统计学意义(P<0.05)。血清ADA活性水平与SLEDAI积分呈正相关(r=0.361,P=0.006)。ESR、hs-CRP与SLEDAI积分无相关性(P>0.05)。结论血清中ADA活性检测可作为监测SLE患者疾病活动度的重要诊断指标。
Objective To investigate the relationship between serum adenosine deaminase （ADA） level and disease status in patients with systemic lupus erythematosus （SLE）.Methods Serum samples of SLE patients（n=57） were selected as SLE group and the serum of healthy adults （n=57） were collected as control group.The serum ADA was tested using ADA coupling purine nucleoside phosphorylase （PNP） and xanthine oxidase （XOD） method.The SLE patients were divided into three groups based on systemic lupus erythematosus disease activity index （SLEDAI）：the remission group （SLEDAI score：0-4）,mild group （SLEDIA score：5-9） and moderate to severe group （SLEDIA score higher than 10）,then the correlation between serum ADA activity and the degree of disease activity in SLE patients were analyzed.In addition,erythrocyte sedimentation rate （ESR） and high sensitivity C-reactive protein （hs-CRP） were collected by retrospective analysis and the correlation between ESR,hs-CRP and the degree of disease activity in SLE patients were analyzed subsequently.Results The average level of serum ADA in the SLE patients and control group were （14.58±6.50） and （8.26±2.05）U/L respectively.The difference was statistically significant （P〈0.005）.The average level of serum ADA in the remission group,mild group and moderate to severe group were （10.94±5.27）,（13.69±4.36） and （17.75±7.09）U/L respectively.The serum ADA level of SLE patients was positively correlated with SLEDAI（r=0.361,P=0.006）,but there were no correlation between ESR,hs-CRP and SLEDAI in SLE patients （P〉0.05）.Conclusion The serum ADA levels could be regarded as a reliable marker to reflect the disease activity of SLE.
出处
《检验医学与临床》
CAS
2017年第9期1275-1276,1279,共3页
Laboratory Medicine and Clinic
关键词
自身免疫性疾病
腺苷脱氨酶
系统性红斑狼疮
系统性红斑狼疮病活动指数
autoimmune disease
adenosine deaminase
systemic lupus erythematosus
systemic lupus erythematosus disease activity index
