摘要
胰腺癌是消化系统恶性程度最高的肿瘤之一,病情进展快,预后极差。近年来,发病率亦明显升高。胰腺癌的治疗模式已由单纯的手术优先,走向包括外科手术、化学治疗和放射治疗等在内的多学科综合治疗,其临床疗效有了明显提高。近年来,随着对胰腺癌发生、发展机制研究的不断深入,研究者对疾病本身有了更加清晰的认识,也为基础临床的转化提供了线索。该研究参考2016年国内外发表的胰腺癌基础和临床研究相关文献,针对胰腺癌发病因素、基础研究热点、外科手术相关进展及化学治疗进展等方面进行综述。
Pancreatic cancer is a highly malignant, fast progressive digestive system neoplasm with poor prognosis, and the incidence has increased significantly in the recent years. The treatment mode of pancreatic cancer has been transformed from surgery-first approach to multidisciplinary approach including surgery, chemotherapy, radiotherapy and other comprehensive treatment modalities, accompanying with significant improvement in clinical efficacy. During the last decade, the molecular mechanism of pancreatic cancer has been explored in depth. Indeed, we had a clearer understanding of the disease, which provides clues for translation of basic research into clinical practice. This review summarized recent high quality studies on pancreatic cancer including pathogenic factor, advances in basic research, and clinical treatment.
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2017年第4期241-250,共10页
China Oncology
基金
国家杰出青年科学基金(81625016)
上海市青年科技英才杨帆计划(17YF1402500)
关键词
胰腺癌
流行病学
基础研究
临床研究
进展
Pancreatic cancer
Epidemiology
Basic research
Clinical research
Progress
