摘要
目的评价术前预防性输注头孢类抗生素对丙泊酚诱导时心电的影响。方法择期女性手术患者50例，ASA分级I或Ⅱ级，年龄20～50岁，体重43～75kg。采用随机数字表法分为头孢呋辛钠组（CEFU组）和头孢硫脒组（CEFA组），每组25例。CEFU组输注头孢呋辛钠、CEFA组输注头孢硫脒后均予丙泊酚（血浆浓度4μg／m1）靶控输注。在头孢呋辛钠或头孢硫脒输注前（T1）、输注完后（T2）和丙泊酚达靶浓度后5min（T3）时采集12导联心电图，测量计算Tp—e间期和Tp-e／QT比值，同时记录MAP和HR。结果与T1时比较，CEFU组T2,3时Tp—e间期延长，CEFA组Tp—e间期延长、Tp—e／QT比值增大（P〈0．05）。2组各时点MAP和HR比较差异无统计学意义（P〉0．05）。结论术前预防性输注头孢呋辛钠较头孢硫脒对丙泊酚麻醉诱导时心电干扰较小。
Objective To evaluate the effects of preoperative prophylactic infusion of cephalospo- fins antibiotics on electrocardiogram （ECG） during anesthesia induction with propofol. Methods Fifty female patients, of American Society of Anesthesiologists physical status I or Ⅱ , aged 20-50 yr, weighing 43-75 kg, scheduled for elective surgery, were divided into cefuroxime sodium group （group CEFU） and cefathiamidine group （ group CEFA） , with 25 patients in each group. After cefuroxime sodium was infused in group CEFU or cefathiamidine was infused in group CEFA, propofol was given by target-controlled infusion （plasma concentration 4 μg/ml）. Before infusion of cefnroxime sodium or eefathiamidine, after com- pletion of infusion and at 5 min after propofol reached the target concentration, 12-lead ECG was recorded, and mean arterial pressure and heart rate were simultaneously recorded. Tp-e interval and Tp-e/QT ratio were calculated. Results Compared with the baseline before infusion of cefuroxime sodium or cefatbiamidine, Tp-e interval was significantly prolonged after completion of infusion and at 5 rain after propofol reached the target concentration in group CEFU, and Tp-e interval was significantly prolonged, and Tp-e/ QT ratio was enlarged in group CEFA （P〈 0.05）. There was no significant difference between the two groups in mean arterial pressure and heart rate at each time point （P〉0. 05）. Conclusion Preoperative prophylactic infusion of cefuroxime sodium produces less ECG interference than preoperative prophylactic infusion of cefathiamidine during anesthesia induction with propofol.
出处
《中华麻醉学杂志》
CSCD
北大核心
2017年第3期260-262,共3页
Chinese Journal of Anesthesiology
关键词
抗菌药
二异丙酚
心电描记术
Anti-bacterial agents
Propofol
Electrocardiography
