摘要
目的:探讨辨证使用中药注射液治疗急性脑梗死的临床疗效和安全性,评价黄芪注射液对急性脑梗死患者血清相关细胞因子及神经功能缺损程度的影响。方法:选择80例急性脑梗死患者并将其随机分为观察组和对照组,各为40例,观察组患者使用黄芪注射液联合血塞通冻干粉进行治疗,对照组则单用血塞通冻干粉进行临床治疗。两组患者疗程均为15 d。结合放射免疫比浊法检测结果对比分析两组患者治疗前和治疗7 d、15 d时的血清hs-CRP水平、IL-1β、IL-6水平及神经功能缺损程度的变化。结果:两组患者的血清hs-CRP水平在梗死7 d时为最高,随后则逐渐降低。治疗前两组患者的血清相关指标检测以及神经功能缺损评分相比,无显著差异(P>0.05);治疗后7 d和15 d时,观察组患者的血清hs-CRP水平、IL-1β、IL-6水平以及神经功能缺损程度均明显低于对照组(P<0.01)。结论:黄芪注射液能够有效地降低急性脑梗死患者的血清相关细胞因子水平,可以减轻患者的炎症反应,同时也有助于改善缺损的神经功能。
Objective ： To investigate the efficacy and safety of TCM injection in the treatment of acute cerebral infarction and evaluate the effect of Astragalus Injection on serum level and neurological function in patients with cerebral infarction. Methods： Eighty eases of patients with acute cerebral infarction and its were randomly divided into observation group and control group,40 eases in each. And the observation group was treated with Astragalus Injection combined with Xuesaitong. The control group used Xuesaitong. The course of treatment in the two groups was 15 d. The changes of ser- um levels of IL- 1 [3 and IL- 6 on 7 d and 15 d and the changes of neurological function of two groups were compared. Results： The serum levels of the two groups were the highest on 7 d, followed by a gradual decrease in the infarction. There was no significant difference （P 〉 0. 05 ） in the serum levels of the two groups before treatment and the levels on 15 d and 7 d in the observation group were significantly lower than those in the control group （P 〈0. 01 ）. Conclusion： Astragalus Injection can effectively reduce serum levels in patients and can relieve the inflammatory reaction of the patients, and also helps to improve the neural thnction defect.
出处
《中华中医药学刊》
CAS
北大核心
2017年第5期1077-1079,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81502147)
关键词
气虚血瘀
急性脑梗死
细胞因子
神经功能缺损程度
Qi deficiency and blood stasis
acute cerebral infarction
cytokines
neurological deficit
