摘要
目的 了解布鲁菌病合并附睾睾丸炎与非合并附睾睾丸炎患者的症状、体征、实验室检查及治疗方案，为临床诊治提供理论依据。方法 收集2010年6月至2016年11月就诊于吉林大学第一医院感染症科223例男性布鲁菌病患者的临床资料，采用回顾性分析方法对22例合并附睾睾丸炎患者与201例非合并附睾睾丸炎患者的临床及实验室特点进行比较分析。应用SPSS 23.0软件对统计结果进行分析，P 〈 0.05为差异有统计学意义。结果 男性布鲁菌病合并附睾睾丸炎患者的发病率为9.87%（22／223）。布鲁菌病合并附睾睾丸炎与非合并附睾睾丸炎患者发病年龄中位数比较，差异无统计学意义（35.5岁比42.0岁，Z = 1.323，P 〉 0.05），但发热率［90.9%（20／22）比69.2%（139／201）］、寒战率［54.5%（12／22）比28.9%（58／201）］、肝肿大率［22.7%（5／22）比3.5%（7／201）］、腹部症状［59.1%（13／22）比17.4%（35／201）］、泌尿系感染症状［31.8%（7／22）比3.5%（7／201）］比较，差异有统计学意义（χ^2 = 4.586、6.076、14.424、20.392、27.059，P均 〈 0.05）。布鲁菌病合并附睾睾丸炎组患者白细胞（WBC）数量（7.9 × 10^9个／L）、红细胞沉降值（ESR，38.0 mm／h）及天冬氨酸氨基转换酶值（AST，110.0 U／L）均高于非合并附睾睾丸炎组（5.1 × 10^9个／L、30.0 mm／h、73.8 U／L），两组间比较差异有统计学意义（Z = 2.239、2.064、2.762，P均 〈 0.05）。布鲁菌病合并附睾睾丸炎组患者经抗生素联合治疗8周有效，布鲁菌病合并附睾睾丸炎组患者退热时间平均为4.5 d，睾丸肿痛缓解时间平均3.9 d，21例患者治愈，仅有1例复发。结论 附睾睾丸炎是布鲁菌病常见并发症，通常有严重的急性临床表现，需临床医师及时识别诊断，抗生素联合8周治疗布鲁菌病合并附睾睾丸炎有效。
Objective To present the distinction on clinical features, laboratory features, treatment schemes between the patients with and without brucellar epididymo-orchitis, and to provide a theoretical basis for clinical diagnosis and treatment. Methods A retrospective analysis of 223 male patients with brucellosis in the First Hospital of Jilin University from June 2010 to November 2016 was carried out. A comparative analysis of the clinical and laboratory features of 22 patients with epididymo-orchitis and 201 cases without epididymo-orchitis was done. The SPSS 23.0 software was used to analyze the statistical results, P 〈 0.05 was defined as statistically significant. Results Epididymo-orchitis occurred in 9.87% （22/223） of all male patients with brucellosis. The median ages of patients with and without epididymo-orchitis were 35.5 and 42.0 years old, respectively, the difference was not statistically significant （Z = 1.323, P 〉 0.05）. Cases with and without epididymo-orchitis of brucellosis with fever [90.9% （20/22） vs 69.2% （139/201）], chills [54.4% （12/22） vs 28.9% （58/201）], hepatomegaly [22.7% （5/22） vs 3.5% （7/201）], abdominal symptoms [59.1% （13/22） vs 17.4% （35/201）], and urinary tract infection symptoms [31.8% （7/22） vs 3.5% （7/201）], the differences were statistically significant （χ^2 = 4.586, 6.076, 14.424, 20.392, 27.059, all P 〈 0.05）. The medians of white blood cell （WBC） count （7.9 × 10^9/L）, erythrocyte sedimentation value （ESR, 38.0 mm/h）, and aspartate aminotransferase （AST, 110.0 U/L） in brucellosis with epididymo-orchitis were higher than those without epididymo-orchitis （5.1 × 10^9/L, 30.0 mm/h, 73.8 U/L）, the differences were statistically significant （Z = 2.239, 2.064, 2.762, all P 〈 0.05）. All brucellosis patients with epididymis-orchitis were treated with antibiotics for 8 weeks. The defervescence time was 4.5 days, the time of pain relief was 3.9 days, 21 patients were cured, and only 1 patient r
出处
《中华地方病学杂志》
CSCD
北大核心
2017年第5期374-377,共4页
Chinese Journal of Endemiology
关键词
布鲁菌病
附睾睾丸炎
临床特点
Brucellosis
Epididymo-orchitis
Clinical features
