期刊文献+

支气管哮喘与Th1/Th2/Th17的相关性分析 被引量:17

The correlation analysis about bronchial asthma and Th1/Tb2/Th17
原文传递
导出
摘要 支气管哮喘是一种涉及多种临床症状,例如咳嗽、气喘、呼吸困难等常见的呼吸系统疾病,其发病率之高严重威胁着人类的健康。哮喘的发病与遗传和环境都有着密切的联系,因其发病机制十分复杂至今尚未明了。众多的细胞及其细胞因子均参与了哮喘的发病过程,其中辅助性T细胞(Thelper,Th)及其亚群(Th1、Th2和Th17)已被证实与支气管哮喘的发生有着十分密切的关系。 Bronchial asthma is a common disease involving the respiratory system. It is characterized by different clinical symptoms such as coughing, wheezing, breathlessness. The high morbidity bronchial asthma threats the health of human beings seriously. The pathogenesis of bronchial asthma is unclear. Studies have shown that asthma is closely linked to heredity and environment. Numerous types of cells and cytokines are involved in the process of the onset of asthma. It has been confirmed that helper T cell (T helper, Th) and its sub- sets (Th1 ,Th2, Th17 ) have close relationship with bronchial asthma.
作者 朱飞 赵铭山
出处 《国际免疫学杂志》 CAS 2017年第2期225-228,共4页 International Journal of Immunology
关键词 哮喘 辅助性T细胞 细胞因子 Asthma Th cell Cytokines
  • 相关文献

参考文献1

二级参考文献31

  • 1Horwitz RJ, Busse WW. Inflammation and asthma [J].Clin Chest Med, 1995,16(4): 583-602. 被引量:1
  • 2Randolph DA, Stephens R, Carruthers CJ, et al. Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation [J]. J Clin Invest,1999, 104(8): 1021-1029. 被引量:1
  • 3Coffman RL, Mocci S, O,Garra A. The stability and reversibility of Th1 and Th2 populations[J]. Curr Top Microbiol Immunol, 1999, 238: 1-12. 被引量:1
  • 4Hansen G, Berry G, DeKruyff RH, et al. Allergenspecific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation[J]. J Clin Invest, 1999, 103(2): 175-183. 被引量:1
  • 5Lucey DR, Clerici M, Shearer GM. Type 1 and type 2cytokine dysregulation in human infectious, neoplastic,and inflammatory diseases [J]. Clin Microbiol Rev,1996, 9(4): 532-562. 被引量:1
  • 6Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins[J]. J Immunol, 1986, 136(7): 2348-2357. 被引量:1
  • 7Maggi E, Biswas P, Del-prefe G, et al. Accumulation of Th2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis [J]. J Immunol, 1991, 146(4): 1169-1174. 被引量:1
  • 8Agarwal S, Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation[J]. Immunity, 1998, 9(6): 765-775. 被引量:1
  • 9Zhang DH, Cohn L, Ray P, et al. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene[J]. J Biol Chem, 1997, 272 (34):21597-21603. 被引量:1
  • 10Siegel MD, Zhang DH, Ray P, et al. Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLEO elements[J]. J Biol Chem, 1995, 270(41): 24548-24555. 被引量:1

共引文献21

同被引文献191

引证文献17

二级引证文献195

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部