摘要
目的精神分裂症与抑郁症患者认知功能障碍的比较研究相关报道尚不多见。文中旨在比较认知功能在精神分裂症和抑郁症患者中的差异。方法选取2015年10月至2016年4月在唐山市开滦精神卫生中心住院的患者,其中包括45例精神分裂症患者、45例抑郁症患者和38例健康者,采用韦氏智力测验(Wechsler Adult Intelligence Scale,WAIS)和威斯康星卡片分类测验(Wisconsin Card Sorting Test,WCST)对所有患者进行认知功能测验并进行比较,其中WAIS评定指标有言语智商(Verbal intelligence quotient,VIQ),操作智商(Performance intelligence quotient,PIQ)及总智商(Full-scale intelligence quotient,FIQ);WCST指标有完成分类数(Categories Completed,Cc)、错误应答数(Errors Response,Re)、持续性错误数(Perseverative Responses Errors,Rpe)。结果 (1)精神分裂症VIQ较抑郁症患者降低[(90.81±19.43)vs(100.85±9.76)分,P=0.003],Rpe升高[(46.58±21.10)vs(32.34±34.28)分,P=0.020];(2)精神分裂症患者FIQ、VIQ值均低于健康者[(95.33±11.51)vs(110.50±5.77)分、(90.81±19.43)vs(112.22±8.82)分,P<0.001]、在PIQ、Cc、Re及Rpe上差异亦有统计学意义(P<0.001);(3)抑郁症患者与健康者在FIQ、VIQ及PIQ和Cc、Re上的差异均具有统计学意义(P<0.001);(4)精神分裂症患者的FIQ、PIQ分别与Cc呈显著正相关(r=0.466、0.575,P<0.05)、与Re呈显著负相关(r=-0.429、-0.459,P<0.05);而VIQ与Re、Rpe呈显著负相关(P<0.05)。抑郁症患者的FIQ、VIQ、PIQ与Cc均呈显著正相关(P<0.05),而与Re均呈显著负相关(P<0.05)。结论抑郁症患者的言语功能优于精神分裂症,可为临床上精神分裂症和抑郁症患者的鉴别提供参考。
Objective Reports are rarely seen about the comparison of cognitive dysfunction between schizophrenia and depression patients. This study aims to investigate the differences in the cognitive function of the patients with schizophrenia or depression. Methods This study included 45 schizophrenia patients, 45 depression patients, and 38 healthy controls. Using Wechsler Adult Intelli-gence Scale （WAIS） and Wisconsin Card Sorting Test （WCST） , we examined the cognitive function of the subjects and compared the findings between different groups. Results The schizophrenia patients, in comparison with the depression patients, showed a signifi-cantly lower verbal intelligence quotient （VIQ） score （90.81±19.43 仍 100.85±9.76,P = 0.0Q3） and a higher perseverative response er-rors （Rpe） score （46.58±21.10 vs 32.34±34.28, P = 0.020） as well as remarkably decreased scores in full-scale intelligence quotient （FIQ） and VIQ as compared with the healthy controls （95.33±11.51 vs 110.50±5.77 and 90.81±19.43 vs 112.22±8.82, P〈0.001）. Be-sides, the schizophrenia patients exhibited statistically significant differences from the healthy subjects in performance intelligence quo-tient （PIQ） , categories completed （Cc） , and errors response （Re） （P〈0.001） , and so did the depression patients in FIQ, VIQ, PIQ, Ce, and Re （P〈0.001）. In the schizophrenia group, FIQ and PIQ were correlated positively with Ce （r = 0.466 and 0.575, P〈0.05） but negatively with Re （r =-0.429 and -0.459, P〈0.05） , while VIQ had a negative correlation with both Re and Rpe （P〈0.05）. In the de-pression group, FIQ, VIQ, and PIQ were all correlated positively with Cc （P〈0.05） but negatively with Re （P〈0.05）. Conclusion Patients with depression have a better verbal function than those with schizophrenia, which may provide some reference for the differentia-tion between schizophrenia and depression.
出处
《医学研究生学报》
CAS
北大核心
2016年第12期1255-1259,共5页
Journal of Medical Postgraduates
基金
国家卫生计生委计划生育与优生重点实验室开放课题(20150006)
2015年度河北省医学科学研究重点课题计划项目(20150050)
2016年度河北省医学科学研究重点课题计划项目(20160218)
河北省中医药管理局2016年度中医药类科研计划课题(2016079)
关键词
精神分裂症
抑郁症
认知功能
韦氏智力测验
威斯康星卡片分类测验
Schizophrenia
Depression
Cognitive function
Wechsler Adult Intelligence Scale
Wisconsin Card Sorting Test
