摘要
目的 探讨原发性肝癌患者应用立体定向体部放射治疗的生物效应剂量.方法 选择原发性肝癌患者80例,按照随机数字表法将患者分为观察组（40例）和对照组（40例）.患者均采用立体定向体部放疗治疗,观察组采用高分次剂量,对照组采用低分次剂量,比较两组不同剂量的放疗效果.结果 观察组治疗后的有效率为77.5%,共有39例患者病情有变化,对照组有效率为55.0%,观察组的有效率明显高于对照组,差异有统计学意义（χ^2=4.528,P=0.033）;观察组患者治疗后6个月、1年以及2年的生存率分别为82.5%、75.0%、72.5%,对照组生存率分别为62.5%、52.5%、50.0%,观察组的生存率高于对照组,差异均有统计学意义（均P〈0.05）;观察组患者总的不良反应发生率为42.5%,对照组患者总的不良反应发生率为72.5%,观察组明显低于对照组,差异有统计学意义（χ^2=7.365,P=0.006）.结论 原发性肝癌患者应用立体定向体部放射治疗其治疗剂量不同,治疗后的疗效也不同,高剂量立体定向体部放射治疗疗效显著,生存率高,且不良反应发生率低,值得临床推广应用.
Objective To study the biological effects of dose radiotherapy for primary liver cancer patients with stereotactic body portion.Methods 80 patients with primary liver cancer were selected.According to a random number table method, all patients were divided into observation group and control group,40 patients in each group.All patients were treated with stereotactic body radiotherapy treatment, the observation group was treated with high dose, while the control group received low-dose.The radiotherapy effects of different doses were analyzed and compared.Results After treatment, the effective rate of the observation group was 77.5%,which of the control group was 55.0%, ,the difference between the two groups was statistically significant （χ^2=4.528,P=0.033）.After treatment for 6 months,1 year and 2 years, the survival rates of the observation group were 77.5%,75.0%,72.5%, which were significantly higher than 55.5%,52.5%,50.0% of the control group （P〈0.05）.The incidence rate of adverse reactions of the observation group was 42.5%, which was significantly lower than 72.5% of the control group （χ^2=7.365,P=0.006）.Conclusion Stereotactic body radiotherapy treatment with different therapeutic dose has different treatment efficacy, high-dose SBRT treatment has significantly higher efficacy, survival rate and lower adverse reactions, which is worthy of clinical application.
出处
《中国基层医药》
CAS
2017年第10期1458-1461,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省宁波市科技局项目（201101A6110088）
关键词
肝肿瘤
放射治疗剂量
Liver neoplasms
Radiotherapy dosage
