摘要
目的:研究氯化钾溶液处方中抑菌剂羟苯乙酯含量。方法:参照中国药典2015年版四部抑菌效力检查法,以药典规定的5种标准菌株(金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌、白色念珠菌和黑曲霉)作为挑战菌,以菌落的对数下降值为指标,分别对不同浓度羟苯乙酯的抑菌效果进行考察,筛选出适宜的羟苯乙酯加入量。结果:氯化钾溶液中羟苯乙酯的加入量为0.05%,对5种挑战菌均有良好的抑制作用,且为最低有效剂量。结论:可选择0.05%羟苯乙酯作为氯化钾溶液的抑菌剂。
Objective ： To investigate the content of ethylparaben in potassium chloride solution. Methods： According to the guid- ance for antibacterial effect test stated in Chinese Pharmacopoeia（ the 4^th volume of 2015 edition）, 5 standard bacterial strains including Staphylococcus aureus,Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger were used as the challenging strains. Using the logarithm decrease of bacteria number as the index, the antimicrobial effectiveness of ethylparaben at different concentrations was studied to screen out the optimal concentration in the solution. Results： The growth of the 5 standard bacterial strains was inhibited effectively by potassium chloride solution containing 0.05% ethylparaben, which was also the minimum effective concentration. Conclusion： 0.05% Ethylparaben is suitable as the bacteriostatic agent for potassium chloride solution.
出处
《中国药师》
CAS
2017年第5期953-955,共3页
China Pharmacist
关键词
氯化钾溶液
羟苯乙酯
含量
抑菌效力
Potassium chloride solution
Ethylparaben
Content
Antimicrobial effectiveness
