摘要
目的:对壳聚糖类医疗器械产品非法添加的抑菌药物尼泊金酯及甲硝唑进行测定。方法:采用高效液相色谱法,色谱柱:ZORBAX Eclipse XDB-C18柱(250 mm×4.6 mm,5μm),流动相:水-乙腈(65∶35),流速1.0 ml·min^(-1),检测波长:254nm,柱温:35℃,进样体积:10μl。结果:栓剂及凝胶剂壳聚糖样品检出尼泊金乙酯,洗剂样品检出甲硝唑。结论:该方法快速,简便,对于全面深入考察壳聚糖类医疗器械产品的非法添加抑菌药物情况具有指导性意义。
Objective： To determine bacteriostatic drugs nipagin esters and metronidazole illegally added to chitosan medical devices. Methods： An HPLC method was used with a ZORBAX Eclipse XDB-C18 （250 mm × 4.6 mm, 5μm） column. The mobile phase was water and acetonitrile（65：35）. The flow rate was 1.0 ml ·min^-1. The detection wavelength was 254 nm. The column temperature was 35℃ and the injection volume was 10 μl. Results： Nipagin esters were detected out in ehitosan suppositories and gel. Metronidazote was detected out in chitosan lotion. Conclusion： The method is simple and fast, which has guiding significance for further comprehensive studies of bacteriostatic drugs illegally added to chitosan medical devices.
出处
《中国药师》
CAS
2017年第5期924-927,共4页
China Pharmacist
关键词
壳聚糖
医疗器械
尼泊金酯
甲硝唑
Chitosan
Medical devices
Nipagin esters
Metronidazole
