摘要
目的:研究3种壮医方对CCl4肝损伤大鼠血清相关指标的影响。方法:抽取144只SD大鼠,雌雄各半,随机分成12组,每组12只,即正常对照组,模型对照组,阳性秋水仙碱组,白花丹消蛊汤高、中、低剂量组,鸡骨草驱蛊汤高、中、低剂量组,七叶化蛊散高、中、低剂量组。除正常对照组外,其余各组均按0.6m L/100g动物体重皮下注射给予40%四氯化碳(CCl4)橄榄油造模,2次/wk,连续造模8wk。造模2wk灌胃给药,连续给药6wk后,大鼠腹主动脉取血,离心取血清,检测各组大鼠血清中血脂、肝功能及肾功能水平,对比各方剂疗效。结果:与模型组相比,七叶化蛊散、白花丹消蛊汤和鸡骨草驱蛊汤各方剂能不同程度改善肝损伤大鼠血清肝肾功能各指标水平(P<0.01或P<0.05)。结论:七叶化蛊散、白花丹消蛊汤和鸡骨草驱蛊汤具有改善肝损伤的作用。
Objective ：To observe the curative effect of Zhuang medicine prescription on serum indicators of he- patic damnification rats. Methods： Rats were randomLy divided into 12 groups： normal group, model group, positive control group, QiYeHnaGu high , middle and low dose group, BaiHuaDanXiao high , middle and low dose group, JiGuCaoQuGu high , middle and low dose group. All rats, except the animal of normal group, were induced by injection of 40% carbon tetrachloride hypodermically twice a week at dose of 0.6mL/100g, and at the same time animal were given rich fat and drug diet. All rats, except the animal of normal group, were treated with medicine. After 8 weeks all rats were sacrificed. The content of hood - fat , liver function and kidney func- tion from blood were determined. Results ： Comparing with model group, the content of bood - fat , liver function and kidney function from blood on Three Zhuang medicine prescription groups were better than that of model group. Conclusions： Three Zhuang medicine prescription are capable of anti - hepatic？ injury action .
作者
钟鸣
陈少锋
赵湘培
苏华
余胜民
Zhong - Min Chen - Shaofeng Zhao - Xiangpei Su - Hua Yu - shengming(Guangxi Institute of Chinese Medicine ＆ Pharmaceutical Science, Nanning 530022, China Guangxi Institute of Nationality Medicine,Nanning 530001 China)
出处
《中国民族医药杂志》
2017年第3期42-44,共3页
Journal of Medicine and Pharmacy of Chinese Minorities
基金
广西科学研究与技术开发计划课题(No.桂科能14123006-6)
关键词
壮医方
肝损伤
大鼠
Zhuang medicine prescription
hepatic injury
Rats
