摘要
目的对慢性阻塞性肺疾病急性加重期(AECOPD)患者的外周血清嗜酸性粒细胞水平与其临床转归的关系进行探讨。方法依据纳入和排除标准,回顾性分析该院2015年3月‐2016年3月入住的56例慢性阻塞性肺疾病急性加重期患者,以其入院时血清嗜酸性粒细胞2%为cut-off值将患者分为非嗜酸性粒细胞组(血嗜酸性粒细胞水平低于2%)与嗜酸性粒细胞组(血嗜酸性粒细胞水平高于并等于2%)。结果两组患者年龄、性别、吸烟史、合并症以及激素使用情况比较差异无统计学意义(P<0.05);血清嗜酸性粒细胞组患者C-反应蛋白水平为(11.4±0.8)mg/L,明显低于非血清嗜酸性粒细胞组患者的(29.2±1.7)mg/L(P<0.05);血清嗜酸性粒细胞组患者住院期间的死亡率为0.00%,略低于非血清嗜酸性粒细胞组患者的的2.86%(P>0.05);非血清嗜酸性粒细胞组患者住院时间为(12.3±0.7)d,长于血清嗜酸性粒细胞组患者的(8.6±0.3)d(P<0.05)。结论血清嗜酸性粒细胞水平较高的AECOPD患者C-反应蛋白水平更低、住院时间更短,提示血清嗜酸性粒细胞水平可作为评判AECOPD病症预后的一项重要生物学指标。
[Objective]To discuss the relationship between peripheral blood eosinophil count and clinical outcome of patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.[Methods]We retrospectively analyzed hospitalized patients with AECOPD admitted to our ward from March 2015 to March 2016.After evaluation of inclusion and exclusion criteria,56 patients were divided into the non-blood eosinophil count group（blood eosinophil count〈 2%） and blood eosinophil count group（blood eosinophil count 2%）.[Results]There was no statistically significant difference in age,sex,smoking history,complications and hormone use between the two groups of patients（P〈0.05）;Compared with the non-blood eosinophil count group,C-reactive protein levels of patients in blood eosinophil count group decreased obviously（P〈0.05）.Although no statistically significant difference was found in hospitalization mortality between the two groups（P〉0.05）,but the length of hospital stay of patients in non-blood eosinophil count group was significantly longer than that of patients in blood eosinophil count group（P〈0.05）.[Conclusion]AECOPD patients with a high level of peripheral blood eosinophil count have lower C-reactive protein level and shorter hospital stay,which suggests that the peripheral blood eosinophil count levels can be used as an important biological indicator for evaluating the disease prognosis of AECOPD.
出处
《中国医学工程》
2017年第3期46-48,共3页
China Medical Engineering
关键词
血清嗜酸性粒细胞
细胞计数
慢性阻塞性肺疾病急性加重期
peripheral blood eosinophil
cell count
acute exacerbation of chronic obstructive pulmonary disease
