摘要
目的评价心脉隆注射液治疗冠心病心力衰竭的疗效,并观察其对病人心脏功能及血浆N末端脑钠肽原(NT-proBNP)水平的影响。方法选取2015年—2016年南阳市中心医院心内科住院治疗的冠心病心力衰竭病人116例,釆用随机、双盲的方法将其分为治疗组和对照组,各58例。两组除了接受常规的西药规范治疗外,治疗组加用心脉隆注射液4 mL加入0.9%氯化钠溶液250 mL(或5%葡萄糖溶液250 mL)静脉输注,每日1次,疗程14 d,比较两组治疗效果,测定两组治疗前后6 min步行距离、左心室舒张末期内径(LVDd)、左心室射血分数(LVEF)及NT-proBNP水平。结果治疗后对照组及治疗组6 min步行距离、LVDd及LVEF均较治疗前明显改善(P<0.05),且治疗组中6 min步行距离、LVDd及LVEF提高幅度均高于对照组(P<0.05);两组病人血浆NT-proBNP水平均较治疗前降低(P<0.05),且治疗组NT-proBNP水平较对照组降低更显著(P<0.05)。结论冠心病心力衰竭病人在西药常规治疗基础上,加用心脉隆注射液治疗,可提高病人的活动耐量,改善病人心脏功能,降低血浆NT-proBNP水平。
Objective To evaluate the effects of Xinmailong injection （XMLI） on cardiac function and plasma N terminal pro B type natriuretic peptide （NT - proBNP） levels in patients with coronary heart disease with chronic heart failure （CHF） .Methods One hun-dred and sixteen patients admitted to the departments of cardiology of Nanyang city central Hospital from 2015 to 2016 were selected and randomly divided into two groups：control group（ n = 58） treated with routine treatment, and treatment group （ n = 58） treated with XMLI and routine treatment for 14 days.The cardiac function,6 minutes walking test,left ventricular diastolic dysfunction（LVDd） , left ventricular ejection fraction（LVEF） and plasma NT proBNP were detected in the two groups before and after treatment.Results After treatment,the 6 minutes distance J_VDdJ_VEF improved in two groups（ P 〈0.05） .The 6 minutes distance, LVDd, LVEF im-proved degree of treatment group were higher than that in control group（ P 〈0.05）.Plasma NT proBNP level was reduced in two groups（ P 〈0.05）, which was lower in treatment group than that in control group（ P 〈0.05） .Conclusion XMLI can improve cardiac function and reduce the level of plasma NT pro BNP in patients with CHF.
出处
《中西医结合心脑血管病杂志》
2017年第7期833-835,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
冠心病
心力衰竭
心脉隆注射液
心脏功能
6
MIN步行试验
N末端脑钠肽原
coronary heart disease
heart failure
Xinmailong injection
heart function
6 minutes walking test
N - te rm in a l pro B type natriuretic peptide
