摘要
以红霉素为印迹分子,聚苯乙烯二维光子晶体为模板,甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸甲酯为交联剂,2,2-二乙氧基苯乙酮为引发剂,紫外光引发聚合,在甲醇-乙酸(9:1,V/V)中洗脱印迹分子,得到能够特异性识别红霉素的分子印迹二维光子晶体水凝胶。通过测试德拜环直径变化,研究了此水凝胶在红霉素溶液中的响应性能。实验结果表明,当红霉素的浓度从0增加到1×10^(-6)mol/L时,德拜环直径增加6 mm,相应的晶格间距减小30 nm。此外,水凝胶在1×10^(-6)mol/L红霉素的类似物罗红霉素、琥乙红霉素溶液中,德拜环直径仅分别增加1.5和2.0 mm,表明此光子晶体水凝胶具有良好的选择性,有望用于红霉素低成本的简易检测。
A molecularly imprinted two -dimensional photonic crystal hydrogel sensor was developed with erythromycin as imprinted molecule, polystyrene two-dimensional photonic crystal as templates, methanol as solvent, methacrylic acid as monomers and ethylene glycol dimethylacrylate as cross- linkers. The imprinted molecule was removed by methanol/acetic acid （9：1,V / V） . The results showed that the diameter of Debye ring increased 6 mm when the concentration of EM changed from 0 to 1 X10＂6 mol/L. Namely the lattice spacing decreased 30 nm. In addition, the diameter of Debye ring only increased 1.5 and 2. 0 mm when the hydrogel immersed in 1X10-6 mol/L roxithromycin （RM） or erythromycin ethylsuccinate （EEs） solution. The result indicated that the sensor had high selectivity and could be used in determination of erythromycin with low cost and easy operation.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2017年第5期727-733,共7页
Chinese Journal of Analytical Chemistry
基金
西北工业大学研究生创意创新种子基金(No.Z2016168)资助
关键词
分子印迹
二维光子晶体
水凝胶
红霉素
传感器
Molecularly imprinting
Two-dimensional photonic crystal
Hydrogel
Erythromycin
Sensor
