摘要
目的研究西安市空气污染物二氧化硫(SO_2)、二氧化氮(NO_2)和PM_(10)对出生缺陷的影响。方法从西安市妇幼保健院获得西安市2010-2015年出生缺陷监测资料,从西安市环境监测站获得同期空气污染资料,从西安市气象站获得同期气象监测资料,采用广义相加模型控制长期趋势、季节、气温和相对湿度影响,探讨空气污染物与出生缺陷的相关性。结果研究期间西安市月平均出生缺陷达89例;SO_2、NO_2、PM_(10)月平均密度分别是34.05、45.13、96.77μg/m^3;月平均温度为13.57℃;相对湿度为63.20%。在广义相加泊松回归模型(GAM)中,空气污染物SO_2、NO_2、PM_(10)与出生缺陷有关且有一定的滞后效应,均在临产前10月的效应达到最大值,各污染物密度每增加10μg/m^3,RR(95%CI)分别为:1.060(1.023~1.097)、1.033(1.014~1.052)和1.018(1.007~1.029),且差异均具有统计学意义(P<0.05)。结论西安市空气污染物SO_2、NO_2、PM_(10)与出生缺陷的发生相关。
Objective To study the effects of air pollution including sulphur dioxide(SO_2),nitrogen dioxide(NO_2)and PM_(10) in Xi'an on birth defects.Methods We collected the birth defects data from Xi'an Maternal and Child Health Hospital,meteorological data from Xi'an Bureau of Meteorology,and the air pollution data from Xi'an Environment Monitoring Station from2010 to 2015.Generalized additive model(GAM)was used to explore the relationship between air pollution and birth defects after adjusting the effects of long-term and seasonal trend,temperature,and relative humidity.Results The monthly average birth defects were 89 cases;the monthly average concentration of SO_2,NO_2 and PM_(10) was 34.05μg/m^3,45.13μg/m^3,and 96.77μg/m^3,respectively.In the GAM,the monthly average temperature was 13.57℃ and the relative humidity was 63.20%.The three kinds of air pollutants all had a certain lag effect in 10 months,which reached the maximum. With an increase of concentration by 10μg/m^3 in three air pollutants,the relative risks and confidence interval of SO_2,NO_2,and PM_(10) were 1.060(1.023-1.097),1.033(1.014-1.052)and1.018(1.007-1.029),with significant differences(P<0.05).Conclusion Exposure to SO_2,NO_2,and PM_(10) may be associated with the risk of birth defects.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2017年第3期366-370,共5页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013)
国家自然科学基金资助项目(No.81230016)~~
