摘要
急性肾损伤(acute kidney injury,AKI)是临床常见的危重症,发病率和导致的患者病死率均较高。早期诊断AKI并及时予以干预治疗,有助于改善患者的预后。目前诊断AKI的主要依据为血清肌酐(serum creatinine,Scr)值升高和尿量改变。然而,Scr值和尿量不能早期反映AKI病情的变化。一些新型生物学标志物可更早预测AKI的发生。笔者拟就早期诊断AKI生物学标志物的研究进展进行阐述。
Acute kidney injury （AKI） is a common clinical condition which induces increased morbidity and mortality. Timely diagnosis and appropriate therapy of AKI can improve outcome. Current diagnosis of AKI is still based on the presence of oliguria and a gradual increase of serum creatinine （Scr） concentration which can not reflect the condition of AKI early. Several novel biomarkers could potentially be useful to predict AKI early in the clinical setting. In this review, we discuss about the clinical evidence of currently available biomarkers in early diagnosis of AKI.
出处
《中华重症医学电子杂志》
2017年第1期40-45,共6页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
关键词
急性肾损伤
生物学标记
早期诊断
Acute kidney injury
Biological markers
Early diagnosis
