摘要
目的 探讨头痛宁胶囊联合尼莫地平治疗原发性血管性头痛的临床疗效.方法 选取76例原发性血管性头痛患者作为研究对象,采用随机数字表法将患者分为对照组（38例）和观察组（38例）.对照组给予尼莫地平口服,观察组在对照组治疗基础上给予头痛宁胶囊治疗.比较两组的临床总有效率、各支血管收缩期峰值流速值（Vs）、各支血管脉动指数值（PI）、止痛时间、复发率和不良反应发生率.结果 对照组和观察组治疗总有效率分别为84.21％和94.74％,观察组高于对照组,差异有统计学意义（χ^2=4.785,P〈0.05）.对照组和观察组患者大脑中动脉（MCA）、大脑前动脉（ACA）、基底动脉（BA）和双锥动脉（VA）的Vs值和PI值均显著改善,且观察组改善状况优于对照组患者,差异均有统计学意义（t=5.385、6.834、7.407、6.651、4.032、5.716、6.203、5.016,均P〈0.05）.观察组和对照组患者止痛时间分别为（5.37 ±5.65）d和（8.56 ±3.26）d,观察组显著短于对照组（t=4.785,P〈0.05）,且复发率显著低于对照组,差异有统计学意义（χ^2 =5.473,P〈0.05）.两组患者不良反应比较,差异无统计学意义（χ^2=0.314,P〉0.05）.结论 头痛宁胶囊联合尼莫地平在原发性血管性头痛治疗中具有较高的应用价值,且临床疗效显著,可改善脑循环和血流量,降低止痛时间和复发率,值得临床推广应用.
Objective To explore the clinical efficacy of Toutongning capsule combined with nimodipine in the treatment of 76 patients with primary vascular headache.Methods 76 patients with primary vascular headache were selected as the research subjects.According to the different surgery,the patients were randomly divided into control group （n =38） and observation group （n =38）.The control group was given compound Danshen injection,while the observation group was given Toutongning capsule combined with nimodipine.The efficacy,the peak systolic velocity（Vs） and pulsatility index（PI） of each vessel,the time of stopping pain,recurrence rate and adverse reaction were compared between the two groups.Results The total effective rate of the observation group was 94.74%,which was higher than 84.21% of the control group,the difference was statistically significant （χ^2 =4.785,P 〈 0.05）.The MCA,ACA,BA,VA value of Vs and PI,the time of stopping pain and recurrence rate in the observation group were better than those in the control group （t =5.385,6.834,7.407,6.651,4.032,5.716,6.203,5.016,4.785,χ^2 =5.473,all P 〈 0.05）.There were no significant differences between the two groups in PCA value of Vs and PI and adverse reaction（t =0.283,0.037,χ^2 =0.314,all P 〈 0.05）.Conclusion Toutongning capsule combined with nimodipine in the treatment of primary vascular headache has high application value and significant effect,and it can promote cerebral circulation,blood flow,time of stopping pain and recurrence rate,so it is worthy of clinical popularization and application.
出处
《中国基层医药》
CAS
2017年第8期1201-1205,共5页
Chinese Journal of Primary Medicine and Pharmacy
