摘要
目的:探讨胸腺肽α-1联合小剂量醋酸泼尼松对高龄重症患者呼吸机肺炎临床疗效及免疫功能影响。方法:收集我院就诊的64例呼吸机肺炎患者,随机分为实验组和对照组,每组32例。两组患者入院后均给予相应的基础治疗,对照组患者给予醋酸泼尼松片治疗,实验组患者在对照组的基础上给予胸腺肽治疗。观察并比较两组患者治疗前后血清CD4^+、CD8^+、CD4^+/CD8^+水平,机械通气时间、ICU停留时间、临床疗效以及不良反应的发生情况。结果:与治疗前相比,两组患者治疗后的CD4^+、CD4^+/CD8^+水平均升高,CD8^+水平均下降,差异具有统计学意义(P<0.05);与对照组相比,实验组患者CD4^+、CD4^+/CD8^+水平较高,CD8^+水平较低,差异具有统计学意义(P<0.05)。与对照组相比,实验组患者的机械通气时间以及ICU停留时间较短,临床治疗有效率较高,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:胸腺肽α-1联合小剂量激素能够提高高龄重症患者呼吸机肺炎患者的临床疗效和免疫功能。
Objective： To investigate the effect ofthymosin α-1 combined with small dose ofprednisone acetate on the clinical ef- ficacy and immune function of senile patients with severe ventilator-associated pneumonia. Methods： 64 cases of pneumonia patients were randomly divided into the experimental group and the control group, 32 cases in each group. Basic treatment were given after ad- mission in both groups, the control group was treated with prednisone acetate tablets, patients in the experimental group were given thy- mosin alpha. The serum CD4^＋, CD8^＋, CD4^＋/CD8^＋ levels, the duration of mechanical ventilation, the length of ICU stay, clinical efficacy and incidence of adverse reactions were observed and compared between two groups of patients before and after treatment. Results： Compared with before treatment, the serum CD4^＋, CD4^＋/CD8^＋ levels were significantly increased, CD8^＋ levels were decreased in both groups of patients after treatment （P〈0.05）; compared with the control group, the serum CD4^＋, CD4^＋/CD8^＋ levels were higher and CD8^＋ level was lower in the experimental group （P〈0.05）; compared with the control group, the duration of mechanical ventilation and ICU stay, the effective rate of treatment was higher in the experimental group（P〈0.05）; no significant difference was found in the incidence of adverse reaction rate be- tween two groups of patients （P〉0.05）. Conclusion： Thymosinct-1 combined with small dose ofprednisone ace- tate could more effectively enhance the clinical efficacy and immune function of senile patients with severe ventilator-associated pneu- monia than prednisone acetate alone.
作者
孟锐
王昱
郁水华
陶琨
刘阳
MENG Rui WANG Yu YU Shui-hua TAO Kun LIU Yang(Department of Geriatrics, Space Center Hospital, Beijing, 100049, China Department of Geriatrics, School of aerospace medicine, Peking University, Beijing, 100049, China)
出处
《现代生物医学进展》
CAS
2017年第11期2087-2089,2067,共4页
Progress in Modern Biomedicine
基金
北京市自然科学基金项目(5982005)
关键词
胸腺肽Α-1
醋酸泼尼松
呼吸机肺炎
临床疗效
Thymosin α-1
Prednisone
Ventilator-associated pneumonia
Clinical efficacy
