摘要
目的探讨血必净注射液对重度急性胰腺炎(severe acute pancreatitis,SAP)炎症因子的影响,并对其临床疗效进行评估.方法将2014-02/2016-02来湖北民族学院附属民大医院治疗的SAP患者94例按照随机数字表法随机分成两组.其中,对照组(n=42)给予生长抑素和氯化钠注射液进行治疗,观察组(n=52)在对照组的基础上加用血必净注射液治疗.采用t检验对两组治疗前后的炎性因子超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、白介素(interleukin,IL)-6及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平进行比较,采用χ~2检验对两组治疗7d后的疗效进行评估.结果治疗后,观察组hS-CRP、IL-6及TNF-α水平分别为35.26 mg/L±8.23 mg/L、35.21 mg/L±6.22 ng/L、49.27 mg/L±6.38 ng/L,明显低于对照组(57.26 mg/L±9.08 mg/L、40.61 mg/L±7.19 ng/L、60.54 mg/L±8.13 ng/L),两组比较差异具有统计学意义(P<0.05).另外,观察组治疗的临床总疗效率为94.23%,明显高于对照组(73.81%,χ~2=7.644,P<0.01).结论血必净注射液可明显降低SAP患者的血清炎症因子水平,提高治疗的总有效率.
AIM To investigate the curative effect of Xuebijing injection for severe acute pancreatitis patients（SAP） and its influence on the inflammatory factors.METHODS From February 2014 to February 2016,94 SAP patients treated at our hospital were randomly divided into either a control group（n = 42） or an observation group（n = 52）.Both groups were given somatostatin and sodium chloride injection,and the observation group was additionally given Xuebijing injection.The changes of inflammatory factors were measured and the curative effect was evaluated after 7 d of treatment.RESULTS After treatment,the levels of high-sensitivity C-reactive protein,interleukin-6 and tumor necrosis factor-α were all significantly lower in the observation group（35.26 mg/L±8.23mg/L,35.21 mg/L±6.22 ng/L,and 49.27mg/L ±6.38 ng/L,respectively） than in the control group（57.26 mg/L ±9.08 mg/L,40.61mg/L ±7.19 ng/L,60.54 mg/L ±8.13 ng/L,respectively,P〈0.05）.The total curative effect rate was significantly higher in the observation group than in the control group（94.23%vs73.81%,χ^2=7.644,P〈0.01）.CONCLUSION Xuebijing injection can significantly decrease the levels of inflammatory factors and improve the total effective rate in patients with SAP.
出处
《世界华人消化杂志》
CAS
2017年第10期929-933,共5页
World Chinese Journal of Digestology
关键词
血必净注射液
生长抑素
重度急性胰腺炎
炎症因子
Xuebijing injection
Somatostatin
Severe acute pancreatitis
Inflammatory factors
