摘要
目的探讨血中C反应蛋白(CRP)和降钙素原(PCT)在新生儿缺血缺氧性脑病(HIE)合并感染监测中的临床价值。方法选取2015年1月至2016年11月在湖南省儿童医院诊断为HIE的68例新生儿,按微生物培养结果分为HIE感染组和HIE非感染组,检测患儿入院时的全血CRP和血清PCT水平,以及入院3 d和出院时的全血CRP水平,并进行统计学分析。另选择30例健康新生儿作为正常对照组。结果入院时HIE感染组的全血CRP、血清PCT水平均明显高于HIE非感染组和正常对照组,差异均有统计学意义[CRP(mg/L):2.39(0.58~10.94)比0.50(0.50~1.54)、0.50(0.50~0.95),PCT(μg/L):1.32(0.23~8.33)比0.50(0.25~0.66)、0.55(0.35~0.69),均P<0.05],而HIE非感染组和正常对照组比较差异无统计学意义[CRP(mg/L):0.50(0.50~1.54)比0.50(0.50~0.95),PCT(μg/L):0.50(0.25~0.66)比0.55(0.35~0.69),均P>0.05];治疗3 d后,HIE感染组全血CRP水平明显高于HIE非感染组[mg/L:2.41(0.50~6.78)比0.58(0.50~3.88),P<0.05];出院时HIE感染组与HIE非感染组全血CRP水平比较差异无统计学意义[mg/L:0.50(0.50~1.02)比0.50(0.50~0.66),P>0.05]。HIE感染组出院时CRP水平明显低于入院时、治疗3 d后[mg/L:0.50(0.50~1.02)比2.39(0.58~10.94)、2.41(0.50~6.78),均P<0.05];而HIE非感染组出院时CRP水平与入院时、治疗3 d后比较差异均无统计学意义[mg/L:0.50(0.50~0.66)比0.50(0.50~1.54)、0.58(0.50~3.88),均P>0.05]。结论全血CRP和血清PCT检测可作为早期识别新生儿HIE合并感染的有效指标;快速、经济、简便的全血CRP动态监测有利于HIE新生儿抗感染治疗的效果评估。
Objective To investigate the clinical value of the whole blood C-reactive protein （CRP） and procalcitonin （PCT） on infection monitoring in neonatal hypoxic-ischemic encephalopathy （HIE）. Methods 68 newborns diagnosed HIE in Hunan Province Children＇s Hospital from January 2015 to November 2016 were recruited and allocated into infection group and non-infection group according to the results of bacterial culture. The level of CRP and PCT were detected and were statistically analyzed on admission, at the third day after admission and at discharge hospital respectively. Meanwhile, 30 healthy neonates were included as the control group. Results On admission, the results of CRP and PCT ininfection group were significant higher than the results of the other two groups [CRP （mg/L）： 2.39 （0.58-10.94） vs. 0.50 （0.50-1.54）, 0.50 （0.50-0.95）, PCT （μg/L）： 1.32 （0.23-8.33） vs. 0.50 （0.25-0.66）, 0.55 （0.35-0.69）, all P 〈 0.05], there were no significant difference between the non-infection group and the control group [CRP （mg/L）： 0.50 （0.50-1.54） vs. 0.50 （0.50-0.95）, PCT （μg/L）： 0.50 （0.25-0.66） vs. 0.55 （0.35-0.69）, all P 〉 0.05]. After 3 days of treatment, CRP in HIE infection group was significantly higher than that in the non-infection group [mg/L： 2.41 （0.50-6.78） vs. 0.58 （0.50-3.88）, P 〈 0.05]. The CRP level in HIE infection group at discharge hospital was lower than that on admission, at the third day after admission [mg/L： 0.50 （0.50-1.02） vs. 2.39 （0.58-10.94）, 2.41 （0.50-6.78）, all P 〈 0.05]. There was no significant difference in CRP level at discharge hospital in the non-infection group compaired with on admission, at the third day after admission [mg/L： 0.50 （0.50-0.66） vs. 0.50 （0.50-1.54）, 0.58 （ 0.50-3.88 ）, all P 〉 0.05] . Conclusions The whole blood CRP and serum PCT can be used as an effective indicators for early identification of neonates with HIE combined infection. Dynamic dete
作者
张聪
黄彩芝
邓永超
李爱国
Zhang Cong Huang Caizhi Deng Yongchao Li Aiguo.(Department of Clinical Laboratory, Hunan Children＇s Hospital, Changsha 410007, Hunan, China)
出处
《实用检验医师杂志》
2017年第1期18-20,共3页
Chinese Journal of Clinical Pathologist
关键词
缺血缺氧性脑病
感染
新生儿
C反应蛋白
降钙素原
Hypoxic-ischemic encephalopathy
Infection
Neonate
C-reactive protein
Procalcitonin
