摘要
目的 探讨吡拉西坦联合依达拉奉治疗急性脑梗死的疗效.方法 选择120例急性脑梗死患者,按照随机数字表法分为对照组和观察组,各60例.两组患者均选用甘露醇脱水降颅内压、阿司匹林抗血小板聚集,给予基础治疗联合营养支持,积极防治并发症,对照组静脉滴注吡拉西坦,观察组在对照组基础上,静脉滴注依达拉奉注射液.两组均治疗14 d.观察两组患者临床疗效,治疗前后神经功能缺损及自理能力评分,治疗前后血液流变学各项指标.结果 治疗后两组神经功能缺损及自理能力评分均较治疗前显著改善（t =3.43、4.12、5.67、6.89,均P＜0.05）,观察组改善情况显著优于对照组（t=2.10、4.21,均P＜0.05）;观察组总有效率为85.00％,高于对照组的70.00％,差异有统计学意义（χ2=4.11,P＜0.05）;治疗后两组血液流变学指标较治疗前均显著改善（t =1.43、2.98、2.32、4.56、1.67、2.11、1.46、1.98,均P＜0.05）,且观察组改善情况显著优于对照组,差异均有统计学意义（t=1.46、2.32、1.67、1.39,均P＜0.05）.结论 吡拉西坦联合依达拉奉对急性脑梗死患者有显著疗效,可改善患者神经功能、认知功能及血液流变学指标,值得临床推广.
Objective To investigate the clinical efficacy of piracetam combined with edaravone in the treatment of patients with acute cerebral infarction.Methods 120 patients with acute cerebral infarction were selected,and they were randomly divided into control group and observation group according to the digital table,60 cases in each group.The patients in both two groups were treated with mannitol to reduce intracranial pressure,aspirin antiplatelet aggregation,combined with basic nutritional support,active prevention and treatment of complications.The control group was intravenously given piracetam.On this basis,the observation group was intravenously given edaravone injection.Both two groups were treated for 14 days.The clinical curative effect,neurological deficit and self-care ability score before and after treatment were observed,and the indicators of hemorheology before and after treatment were observed.Results Mter treatment,the neurological deficit and self-care ability scores of the two groups were significantly improved（t =3.43,4.12,5.67,6.89,all P 〈 0.05）,the improvements of the observation group were significantly better than those of the control group（t =2.10,4.21,all P 〈 0.05）.The total effective rate of the observation group was 85.00%,which was higher than 70.00% of the control group,the difference was statistically significant （χ2 =4.11,P 〈 0.05）.After treatment,the indicators of hemorheology of the two groups were significantly improved （t =1.43,2.98,2.32,4.56,1.67,2.11,1.46,1.98,all P 〈 0.05）,and the improvements of the observation group were significantly better than those of the control group （t =1.46,2.32,1.67,1.39,all P 〈 0.05）.Conclusion Piracetam combined with edaravone can significantly improve the neurological function,cognitive function and hemorheology of patients with acute cerebral infarction.
出处
《中国基层医药》
CAS
2017年第9期1285-1288,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑梗死
依达拉奉
吡拉西坦
认知
Brain Infarction
Edaravone
Piracetam
Cognition
