摘要
阿尔兹海默症(Alzheimer’s disease,AD)又称原发性老年痴呆症,是一种中枢神经系统退行性疾病,主要表现为渐进性记忆障碍、认知功能障碍、人格改变及语言障碍等神经精神症状。由于其发病机制复杂,尽管人们已对该病研究百余年,但关于AD发病的具体机制仍不十分清楚。脑内金属离子失衡,加速β淀粉样蛋白沉积和Tau蛋白聚集,与AD的发生发展密切相关。本文对金属离子(如锌、铜、铁)在AD发病机制中的作用进行概述。
Alzheimer’s disease（AD）,also known as primary dementia,is a complex neurodegenerative disorder,with patients develop neuropsychiatric symptoms of progressive memory impairment,cognitive dysfunction,personality change and language disorders,etc.Due to the complexity of its pathogenesis,it is not really clear what the mechanism related to AD works up to now.The aberrant of metal homeostasis in the brain may be one of the main reasons that induce amyloidβ-protein deposition and Tau protein aggregation,and accelerate the development of AD.In this paper,the role of metal ions,such as zinc,copper and iron in AD pathogenesis is overviewed.
出处
《中国现代应用药学》
CAS
CSCD
2017年第3期470-474,共5页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金(81302646)
浙江省科技计划项目(2015F50015)
