摘要
目的:研究血清中(1,3)-β-D-葡聚糖检测对深部真菌感染的临床意义。方法:回顾性分析1 100例住院患者检测血清(1,3)-β-D-葡聚糖(真菌G试验)结果。结果:真菌G试验灵敏度为78.0%,特异度为89.9%,阳性预测值74.8%,阴性预测值91.4%,真菌G试验与临床诊断结果差异有统计学意义(χ2=491.25,P<0.01)。真菌培养灵敏度为48.9%,特异度为92.3%,阳性预测值71.0%,阴性预测值82.5%,真菌培养与临床诊断结果差异有统计学意义(χ2=239.34,P<0.01)。结论:真菌G试验的检测方法快速、阴性预示值高。传统的真菌培养耗时长,特异性虽高,但标本取材易受污染。建议临床对疑似深部真菌感染时,同时进行真菌G试验和病原培养以提高诊断的敏感性和特异性。
Objective： To investigate the clinical value of the serum （1,3）-β-D-glucan assay in the diagnosis of invasive fungal infection. Methods：The serum levels of（ 1,3 ）-β-D-glucan in 1 100 patients were retrospectively analyzed. Results：The sensitivity, specificity, positive predictive value and negative predictive value of the （ 1,3 ）-β-D-glucan assay were 78.0% , 89.9% , 74.8% and 91.4%, respectively, the difference between the result of fungal G test and clinical diagnosis was statistically significant（χ^2= 491.25, P 〈 0.01 ）. The sensitivity, specificity, positive predictive value and negative predictive value of fungal culture were 48.9%,92.3%, 71.0% and 82.5% , respectively, the difference between the result of fungal G test and clinical diagnosis was statistically significant（χ^2 = 239.34, P 〈 0.01 ）. Conclusions：The（ 1, 3 ）-β-D-glucan assay is rapid and high negative predictive value. The conventional fungal culture is long time consuming, high specificity and susceptibility to contamination. The fungal G test combined with fungal culture can improve the sensitivity and specificity of the clinical diagnosis in suspect invasive fungal infection.
出处
《蚌埠医学院学报》
CAS
2017年第1期104-105,110,共3页
Journal of Bengbu Medical College
