摘要
目的:系统评价5-氨基酮戊酸光动力疗法(ALA-PDT)对扁平疣治疗的疗效和安全性。方法:计算机检索万方数据、维普期刊、中国期刊全文数据库(CNKI)、Pubmed数据库及EBSCO数据库自1990年1月—2015年9月间文献,依照拟定的纳入和排除标准进行文献筛选和质量评价,采用Review Manager 5.2软件对纳入的文献进行Meta分析。结果:共纳入6个随机对照试验,共计547例患者。Meta分析结果示ALA-PDT治疗扁平疣在复发率及不良反应方面优于CO2激光和液氮冷冻治疗,在痊愈率方面优于外用咪喹莫特乳膏。结论:ALA-PDT对治疗扁平疣有较好的疗效和安全性,值得临床应用。
Objective： To evaluate the efficacy and safety of 5-aminolevulinic acid-photodynamic therapy（ALA-PDT） for flat warts. Methods： Data in randomized controlled trials （RCTs） from January 1990 to September 2015 were collected from databases, such as Wanfang data, VIP, CNKI, Pubmed and EBSCO. After inclusion and exclusion according to respective cri- teria, data were analyzed using Revman 5.2 software. Results： Five hundred and forty-seven patients were included in six RCTs. Meta-analysis showed that ALA-PDT was superior to CO2 laser and cryotherapy with respect to recurrence rates and adverse reactions. Regarding the cure rates, ALA-PDT group was superior to infiquimod cream. Conclusion： ALA-PDT is ef- fective and safe for flat warts.
出处
《临床皮肤科杂志》
CSCD
北大核心
2017年第5期313-317,共5页
Journal of Clinical Dermatology
