摘要
目的:研究小柴胡汤联合静脉化疗对晚期乳腺癌患者肿瘤标志物及免疫功能的影响。方法:收集2012年5月~2015年11月间湖北省武汉市新洲区中医医院收治的晚期乳腺癌患者76例,根据治疗方式不同,分为接受小柴胡汤联合静脉化疗的联合治疗组34例、接受单纯静脉化疗的对照组42例,治疗周期均为3月。治疗前、治疗3月后,采用ELISA法检测血清广谱肿瘤标志物、乳腺癌特异性肿瘤标志物含量;采用流式细胞仪检测外周血细胞免疫功能指标水平,采用免疫透射比浊法测定体液免疫指标含量。结果:治疗前,两组患者血清肿瘤标志物含量,外周血细胞免疫、体液免疫指标水平差异无统计学意义(P>0.05);治疗3月后,联合治疗组患者血清中广谱肿瘤标志物CEA、CA153、CA125的含量低于对照组患者,乳腺癌特异性肿瘤标志物IGF-1、MK、sEC、TK1的含量低于对照组患者(P<0.05);联合治疗组外周血中CD3^+、CD4^+T淋巴细胞水平及CD4^+/CD8^+比值高于对照组患者,CD8^+T淋巴细胞水平低于对照组患者,外周血中IgG、IgA、IgM含量高于对照组患者(P<0.05)。结论:小柴胡汤联合静脉化疗可降低晚期乳腺癌病情严重程度,优化机体免疫功能。
Objective：To study the effect of Xiao Chaihu Tang combined with intravenous chemotherapy on tumor markers and immune function in patients with advanced breast cancer.Methods：A total of 76 patients with advanced breast cancer treated in our hospital between May 2012 and November 2015 were collected and divided into the combined treatment group（n=34）who accepted Xiao Chaihu Tang combined with intravenous chemotherapy and the control group（n=42）who accepted intravenous chemotherapy alone according to different treatment,and the treatment cycle was 3 months for both groups.Before treatment and 3 months after treatment,ELISA method was used to detect serum levels of broad-spectrum tumor markers and breast cancer-specific tumor markers;flow cytometer was used to detect cellular immune function index levels,and turbidimetric immunoassay was used to detect humoral immune function index levels in peripheral blood.Results：Before treatment,differences in serum tumor marker levels as well as cellular immunity and humoral immunity index levels in peripheral blood were not statistically significant between two groups of patients（P〉0.05）;after 3 months of treatment,broad-spectrum tumor markers CEA,CA153 and CA125levels in serum of combined treatment group were significantly lower than those of control group,and breast cancer-specific tumor markers IGF-1,MK,sEC and TK1 levels were lower than those of control group（P〈0.05）;CD3^＋and CD4^＋T lymphocyte levels as well as CD4^＋/CD8^＋ratio in peripheral blood of combined treatment group were significantly higher than those of control group while CD8^＋T lymphocyte level was lower than that of control group,and IgG,IgA and IgM levels in peripheral blood were significantly higher than those of control group（P〈0.05）.Conclusions：Xiao Chaihu Tang combined with intravenous chemotherapy can decrease the severity of advanced breast cancer and optimize the body＇s immune function.
出处
《海南医学院学报》
CAS
2017年第5期669-672,共4页
Journal of Hainan Medical University
基金
武汉市卫生局一般项目(201503021)~~
关键词
晚期乳腺癌
小柴胡汤
静脉化疗
肿瘤标志物
免疫功能
Advanced breast cancer
Xiao Chaihu Tang
Intravenous chemotherapy
Tumor markers
Immune function
