摘要
目的:采用层次分析法(AHP)对抗抑郁药物进行风险效益评价,得出各个药物的综合评分值并进行排序,为临床合理用药提供帮助。方法:建立层次分析法目标图,首先确定目标层,即决策的总目标;其次确定准则层,通过各指标对待评价药物进行风险效益评估;最后是方案层,即本次研究要评价的药物。目标图建立以后,查找待评价药物的相关Meta分析文献,通过Meta分析结果,确定各个属性的相对重要性,并进行指标赋权和矩阵计算,得出各方案的风险值,效益值和综合评分。使用Expert Choice软件进行敏感性分析。结果:米氮平、文拉法辛、西酞普兰和舍曲林的综合评分值分别为0.305 4,0.304 6,0.294 6和0.095 4。效益值分别为0.313 0,0.313 0,0.313 0,0.063 0。风险值分别为0.196 2,0.282 0,0.353 5和0.168 9。各层次的判断矩阵的一致性比率(CR)均小于0.1,即都通过了一致性检验。结论:综合评分最高的是米氮平,最低的是舍曲林。效益值最低的是舍曲林,风险值最高的是西酞普兰。
Objective：To evaluate risk and benefit of antidepressant using analytic hierarchy process （AHP）, comprehensive scores of each antidepressant were obtained and ranked for clinical rational use of drug. Methods：The AHP disaggregates a complex decision problem into different hierarchical levels. The first step involve defining the goal of the decision. In the next step, identifying criteria, the risk and benefit of antidepressants can be assessed independently. And fi- nally, making comparisons among the alternatives. The hierarchical decision model was defined, then relevant literature of Meta-analysis were searched to confirm the relative importance of each attributive. The risk value, benefit value and com- prehensive score were obtained by using the AHP. The Expert Choice software was used for the sensitivity analysis. Re. suits ：The comprehensive scores of mirtazapine, venlafaxine, citalopram and sertraline were 0.305 4, 0.304 6, 0.294 6 and 0.095 4, respectively. The benefit value of mirtazapine, venlafaxine, citalopram and sertraline were 0.313 0, 0. 313 0, 0. 313 0 and 0. 063 0, respectively. The risk value of mirtazapine, venlafaxine, citalopram and sertraline were 0. 196 2, 0.282 0, 0.353 5 and 0. 168 9, respectively. The consistency ratio （CR） of judgment matrix were less than 0.1, which passed the consistency inspection. Conclusion：The highest comprehensive scores was mirtazapine and the lowest one was sertraline, sertraline had the lowest benefit value and citalopram had the highest risk value.
出处
《药物流行病学杂志》
CAS
2017年第4期225-229,293,共6页
Chinese Journal of Pharmacoepidemiology
关键词
层次分析法
风险
效益
米氮平
文拉法辛
西酞普兰
舍曲林
Analytic hierarchy process
Risk
Benefit
Mirtazapine
Venlafaxine
Citalopram
Sertraline
