摘要
目的 :探讨用血必净联合乌司他丁治疗脓毒血症的临床效果。方法 :将2012年9月至2015年12月期间在西南医科大学附属医院急诊科接受治疗的216例脓毒血症患者随机分为研究A组与研究B组,每组各有108例患者。用血必净对研究B组患者进行治疗,用血必净联合乌司他丁对研究A组患者进行治疗。治疗结束后,观察对比两组患者TNF-α(肿瘤坏死因子-α)、IL-6(白介素-6)及血浆PCT的水平。结果 :在治疗后,两组患者TNF-α、IL-6及血浆PCT的水平均明显低于治疗前,差异具有统计学意义(P<0.05)。在治疗后研究A组患者TNF-α、IL-6及血浆PCT的水平均明显低于研究B组患者,差异具有统计学意义(P<0.05)。结论 :用血必净联合乌司他丁治疗脓毒血症可显著降低患者体内炎症因子的水平,改善其免疫系统的功能,进而提高其免疫力。
Objective To study the effect of Xuebijing combined with ulinastatin on immune function in patients with sepsis. Methods Random selected from our hospital from September 2012 to December 2015 to receive and treat the patients with sepsis in 216 cases as the research object, and were randomly divided into control group and study group A and group B, 108 cases in each group. Treat group B with Xuebijing, A group treated with ulinastatin combined with Xuebijing therapy, compare TNF-α level, IL-6 level, PCT level of group A and group B. Results A group and B group were different after treatment of various clinical indicators of the level of tumor necrosis factor and interleukin TNF-α levels of factor IL-6 level and PCT level compared with before treatment were significantly decreased（P〈0.05）.The indicators of TNF-α, IL-6 level, PCT of group A are lower than group B, discrepancy of two groups was statistically significant（P〈0.05）. Conclusion Treat sepsis with Xuebijing combined with ulinastatin can reduce inflammation level, improve immune function of patients.
