摘要
目的:探讨平阳霉素联合放疗治疗晚期皮肤癌的临床效果。方法:选取2012年1月至2016年1月在我院治疗的皮肤癌患者100例,将患者随机分为观察组(n=44)和对照组(n=56),观察组给予讨平阳霉素联合放疗治疗,对照组给予放疗治疗,观察两组治疗疗效及不良反应情况。结果:观察组近期疗效优于对照组(P<0.05),其中观察组完全缓解(CR)和部分缓解(PR)比例分别为50.00%和34.09%;观察组1、2、3年生存率分别为90.70%、77.90%和61.20%,对照组1、2、3年生存率分别为85.20%、68.10%和50.40%,观察组远期疗效优于对照组(P<0.05);观察组和对照组患者在恶心呕吐、白细胞减少、口腔炎及脱发等不良反应发生率差异比较无统计学意义(P>0.05)。结论:平阳霉素联合放疗治疗晚期皮肤癌安全有效,值得临床推广使用。
Objective： To investigate the clinical effect of pingyangmycinc combined with radiotherapy in the treatment of advanced skin cancer. Methods： From January 2012 to January 2016,selected 100 cases of skin cancer in our hospital,the patients were randomly divided into observation group（ n = 44） and control group（ n = 56）,the observation group were treated with pingyangmycinc combined with radiotherapy,and the control group were treated with radiotherapy,observed the curative effect and adverse reaction of the two groups. Results： The short-term curative efficacy of the observation group was significantly better than that of the control group（ P 〈 0.05）,the proportion of complete remission（ CR） and partial remission（ PR） were50.00% and 34.09%; Observation group 1,2,3 year survival rates were 90.70%,77.90% and 61.20%,the control group 1,2,3 year survival rates were 85.20%,68.10% and 50.40%,the observation group long-term curative effect was significantly better than the control group（ P 〈 0.05）; The observation group and the control group nausea and vomiting,leukopenia,stomatitis and alopecia adverse reactions difference were not statistically significant（ P 〉 0.05）. Conclusion： It is safe and effective for the treatment of advanced skin cancer with pingyangmycinc combined with radiotherapy,which is worthy of clinical application.
出处
《河北医学》
CAS
2017年第3期427-430,共4页
Hebei Medicine
基金
辽宁省卫生厅科研课题
(编号:1300571)
关键词
平阳霉素
放疗
皮肤癌
晚期
Pingyangmycinc
Radiotherapy
Skin cancer
Advanced stage
