摘要
目的 分析左乙拉西坦对癫痫患者血清瘦素及hs-CRP水平的影响,以期探寻治疗癫痫患者的最佳方案。方法 收集于我院癫痫患者150例,随机分为实验组和对照组,每组各75例,对照组患者给予丙戊酸钠、卡马西平,实验组患者给予左乙拉西坦。比较治疗前后2组患者血清瘦素（Leptin,LP）、超敏C反应蛋白（hypersensitive C-reactive protein,hs-CRP）、总胆固醇（total cholesterol,TC）、甘油三酯（Triglyceride,TG）。结果 治疗结束后与治疗前相比相比,实验组患者血清LP、TC及TG水平无显著变化,hs-CRP明显降低（P〈0.05）,且实验组各项指标均明显低于对照组（P〈0.05）。结论 左乙拉西坦癫痫患者比用丙戊酸钠和卡马西平联合治疗效果更好。
Objective To investigate the effect of the serum leptin and hs-CRP levels by Levetiracetam in patients with epilepsy. Methods 1 5 0 patients with epilepsy from our hospital were selected and randomly divided into the control group and the experiment group with 7 5 cases in each group. The control group were treated by sodium valproate and carbamazepine and the experiment group were treated in the base of the control group with Levetiracetam. The LP,hs-CRP,TC and TG levels were compared before and after treatment. Results Compared with before treatment, there was no significant change in serum LP, TC and TG levels,the hs-CRP were lower（P 〈 0 . 0 5 ） ,and the indexes of the experimental group were significantly lower han those of the control group（ P 〈 0. 05 ） . Conclusion Levetiracetam to the pediatric epilepsy patients to good therapeutic effect, reduce the side effects of hazards, speculated that the mechanism may be related to the left B Raschig Tan to maintain patients serum leptin, triglyceride, total cholesterol levels, reduce the levels of high sensitivity C reactive protein related.
出处
《中国生化药物杂志》
CAS
2017年第4期232-234,共3页
Chinese Journal of Biochemical Pharmaceutics
